Titel "Korte inhoud" "Improved fixed point optimality conditions for mixed norms minisum location" "We improve and extend sufficient conditions for an optimal solution to happen at a fixed point in a single facility minisum location model with mixed lp norms recently proposed by Brimberg, Love and Mladenovic." "Fixed Effects Testing in High-Dimensional Linear Mixed Models" "Gerda Claeskens" "Many scientific and engineering challenges—ranging from pharmacokinetic drug dosage allocation and personalized medicine to marketing mix (4Ps) recommendations—require an understanding of the unobserved heterogeneity to develop the best decision making-processes. In this article, we develop a hypothesis test and the corresponding p-value for testing for the significance of the homogeneous structure in linear mixed models. A robust matching moment construction is used for creating a test that adapts to the size of the model sparsity. When unobserved heterogeneity at a cluster level is constant, we show that our test is both consistent and unbiased even when the dimension of the model is extremely high. Our theoretical results rely on a new family of adaptive sparse estimators of the fixed effects that do not require consistent estimation of the random effects. Moreover, our inference results do not require consistent model selection. We showcase that moment matching can be extended to nonlinear mixed effects models and to generalized linear mixed effects models. In numerical and real data experiments, we find that the developed method is extremely accurate, that it adapts to the size of the underlying model and is decidedly powerful in the presence of irrelevant covariates." "When good feelings turn mixed: Affective dynamics and Big Five trait predictors of mixed emotions in daily life" "Peter Koval, Peter Kuppens" "Development of CliniPup, a Serious Game Aimed at Reducing Perioperative Anxiety and Pain in Children: Mixed Methods Study" "June van Aalst, Jaan Toelen, Karel Allegaert" "BACKGROUND: An increasing number of children undergo ambulatory surgery each year, and a significant proportion experience substantial preoperative anxiety and postoperative pain. The management of perioperative anxiety and pain remains challenging in children and is inadequate, which negatively impacts the physical, psychosocial, and economic outcomes. Existing nonpharmacological interventions are costly, time consuming, vary in availability, and lack benefits. Therefore, there is a need for an evidence-based, accessible, nonpharmacological intervention as an adjunct to existing pharmacological alternatives to reduce perioperative anxiety and pain in children undergoing ambulatory surgery. Technology-enabled interventions have been proposed as a method to address the unmet need in this setting. In particular, serious games hold a unique potential to change health beliefs and behaviors in children. OBJECTIVE: The objective of this research was to describe the rationale, scientific evidence, design aspects, and features of CliniPup, a serious game aimed at reducing perioperative anxiety and pain in children undergoing ambulatory surgery. METHODS: The SERES Framework for serious game development was used to create the serious game, CliniPup. In particular, we used a mixed methods approach that consisted of a structured literature review supplemented with ethnographic research, such as expert interviews and a time-motion exercise. The resulting scientific evidence base was leveraged to ensure that the resulting serious game was relevant, realistic, and theory driven. A participatory design approach was applied, wherein clinical experts qualitatively reviewed several versions of the serious game, and an iterative creative process was used to integrate the applicable feedback. RESULTS: CliniPup, a serious game, was developed to incorporate a scientific evidence base from a structured literature review, realistic content collected during ethnographic research such as expert interviews, explicit pedagogical objectives from scientific literature, and game mechanics and user interface design that address key aspects of the evidence. CONCLUSIONS: This report details the systematic development of CliniPup, a serious game aimed at reducing perioperative anxiety and pain in children undergoing ambulatory surgery. Clinical experts validated CliniPup's underlying scientific evidence base and design foundations, suggesting that it was well designed for preliminary evaluation in the target population. An evaluation plan is proposed and briefly described." "Linear mixed modelling for data from a double mixed factorial design with covariates: A case-study on semantic categorization response times." "Jorge Gonzalez Burgos, Paul De Boeck, Francis Tuerlinckx" "Linear mixed modelling is a useful approach for double mixed factorial designs with covariates. It is explained how these designs are appropriate for the study of human behaviour as a function of characteristics of individuals and situations and stimuli in the situations. The behaviour of subjects nested in types of individual responding to stimuli nested in types of stimuli defines a mixed factorial design. The inclusion of additional covariates of the observational units can help to explain the behaviour under study further. A linear mixed modelling approach for such designs allows a combined focus on fixed effects (general effects) and individual and stimulus differences in these effects. This combination has the potential to advance the integration of two different subdisciplines of psychology, general psychology and differential psychology, so that they can borrow strength from each other. An application is presented with semantic categorization response time data from a factorial design with age groups by word types and with age of acquisition as an additional covariate of the words. The results throw light on the processes underlying the effect of age of acquisition and on individual differences and word differences. © 2013 Royal Statistical Society." "Mixed Parents, Mixed Results: Testing the Effects of Cross-nativity Partnership on Children's Educational Attainment" "Viktor Emonds" "In this article, we have used panel data from the Children of Immigrants Longitudinal Survey (N=3,337) to test several mechanisms (English proficiency, friends with native parents, parental socioeconomic status [SES], educational attitudes, bilingualism, and family stability) by which mixed parents (one native, one foreign-born) affect their children’s educational attainment differently from immigrant parents (both foreign-born), using a multiple mediator model. We found that children from mixed parents benefited from higher parental human capital and a higher English proficiency and were set back by lower educational attitudes and less stable family situation. However, bilingualism offered no significant advantages or disadvantages for children of mixed parents. Having more friends from native-born parents had a surprising negative effect. The total indirect effect was slightly negative and a substantial negative direct effect of growing up with mixed parents on educational attainment remains. Some of the effects depend on the sex of the native partner. Implications and limitations are discussed." "Control of continuous mixed solution mixed product removal crystallization processes" "Robert Dürr" "In this paper continuous mixed solution mixed product removal (MSMPR) crystallization is considered. This process has been studied well, however, different aspects, in particular, process modeling, monitoring and control remain challenging. Within this paper we will present a new approach for online measurement of the crystal size distribution. Furthermore, unscented Kalman filtering is applied to overcome biased concentration measurement. Finally, a discrepancy-based control is applied to continuous MSMPR crystallization and its closed-loop performance is evaluated" "Characterization of a mixed culture that reductively dechlorinates mixed chlorinated ethenes and ethanes" "Vincenzo Maffione, Harmien Verstraete, Willy Verstraete, Nico Boon" "In the quest for a valid bioaugmenting agent for applications in real sites, an anaerobic mixed culture able to reductively dechlorinate a mixture of C2 chlorinated aliphatic hydrocarbons (CAHs), has been enriched over a period of several years from a groundwater historically contaminated with 1,2-dichloroethane (1,2-DCA) and other C2 CAHs, such as tetrachloroethene (PCE). The culture, named Multidechlorobac, has been analysed for its microbial composition, and the effects of inoculum amount on its dechlorination capabilities have been tested on subcultures prepared in non-sterile conditions, using 1,2-DCA and PCE as final electron acceptors. Lactate, yeast extract and molasses have been used as both carbon and electron sources. Multidechlorobac consisted of both dechlorinators, such as Dehalococcoides ethenogenes strain 195 and Desulfitobacterium sp., and non-dechlorinators belonging to Bacteroidetes, Proteobacteria and Firmicutes. While the former ones are directly involved in the degradation of the pollutants, the latter support the process by providing hydrogen, which acts as electron donor in the dechlorination. The initial bacterial concentration was about 108 cells mL-1, and subcultures were able to degrade the pollutants at 10 % inoculum. Higher dilutions resulted in a loss of dechlorinating capacity, leading to a slower or unsuccessful treatment, even though dechlorination was still observed for 1,2-DCA. Multidechlorobac was effective in the degradation of pollutants, and it was found to be robust and easy to grow, in comparison with pure cultures. The culture might be successfully used as bioaugmenting agent in the clean-up of sites polluted with C2 chlorinated aliphatic hydrocarbons." "The influence of pore aperture, volume and functionality of isoreticular gmelinite zeolitic imidazolate frameworks on the mixed gas CO2/N2 and CO2/CH4 separation performance in mixed matrix membranes" "Raymond Thür, Ivo Vankelecom" "Investigation of ZIF-78 Morphology and Feed Composition on the Mixed Gas CO2/N2 Separation Performance in Mixed Matrix Membranes" "Ivo Vankelecom"