Prokaryote toxin-antitoxin modules: complex regulation of an unclear function Vrije Universiteit Brussel
A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels KU Leuven
Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity KU Leuven
A Fair Assessment of Evaluation Tools for the Murine Microbead Occlusion Model of Glaucoma KU Leuven
Improving the yield of recalcitrant Nanobodies® by simple modifications to the standard protocol Vrije Universiteit Brussel
Nanobodies are single-domain antibody constructs derived from the variable regions of heavy chain only (VHH) camelid IgGs. Their small size and single gene format make them amenable to various molecular biology applications that require a protein affinity-based approach. These features, in addition to their high solubility, allows their periplasmic expression, extraction and purification in E. coli systems with relative ease, using ...
In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach Vrije Universiteit Brussel
The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises serious ethical questions, but is also rather poorly predictive of human safety towards chemicals. Increasing attention is, therefore, being paid to the development of non-animal and human-based testing schemes, which rely to a great extent on in vitro methodology. The present paper ...