Publicaties

1 - 10 of 56 resultaten

Sorteren op
Zoek term:

Ceftazidime-avibactam and aztreonam combination for Carbapenem-resistant Enterobacterales bloodstream infections with presumed Metallo-β-lactamase production: a systematic review and meta-analysis Instituut voor Tropische Geneeskunde

Nitin Gupta, Carl Gregory Boodman, Parikshit Prayag, Abi Manesh, Tirlangi Praveen Kumar

INTRODUCTION: Carbapenem-resistant Enterobacterales (CRE) due to Metallo-β-lactamase (MBL) production are treated with either polymyxins or the novel combination of ceftazidime-avibactam and aztreonam (AA). This study aims to evaluate the 30-day mortality of AA in patients with BSI caused by MBL-CRE infections.

METHODOLOGY: In this systematic review and meta-analysis, all articles up to June 2023 were screened using search terms like ...

Hidden Burden of Bartonella quintana on the African Continent: should the bacterial infection be considered a neglected tropical disease? Instituut voor Tropische Geneeskunde

Carl Gregory Boodman, Noah Fongwen, Alfonso J Pecoraro, Adane Mihret, Hiwot Abayneh, Pierre-Edouard Fournier, Nitin Gupta, Johan van Griensven

Bartonella quintana is a louse-borne gram-negative bacillus that remains a poorly characterized cause of bacteremia, fever, and infective endocarditis. Due to the link with pediculosis, B quintana transmission is tied to poverty, conflict, overcrowding, and inadequate water access to maintain personal hygiene. Although these risk factors may be present globally, we argue that a substantial burden of undocumented B quintana infection occurs in ...

Assessing viral metagenomics for the diagnosis of acute undifferentiated fever in returned travellers: a multicenter cohort study Instituut voor Tropische Geneeskunde

Daniel Camprubí-Ferrer, A Tomazatos, Leire Balerdi-Sarasola, LG Cobuccio, Steven Van Den Broucke, B Horváth, Marjan Van Esbroeck, Miguel J. Martinez, J Gandasegui, Carme Subirà, et al.
Background
Up to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centres. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, evidence of its usefulness in imported fever is very limited.

Methods
Travellers returning with fever were prospectively recruited in three referral clinics from November 2017 to November 2019. Unbiased ...

Duration of Fever in Patients with Dengue: A Systematic Review and Meta-Analysis Instituut voor Tropische Geneeskunde

Carl Gregory Boodman, Christelle Genevieve Jouego, Steven Van Den Broucke
Dengue is an acute febrile illness endemic to tropical countries and associated with high mortality rates. Despite being a viral infection, there is rampant misuse of antibiotics in patients with dengue because of perceived delay in defervescence and fear of secondary bacterial infections. Therefore, there is a need to establish the average fever duration with a confidence interval among patients with dengue. Studies up to October 21, 2022 from ...

Bartonella quintana detection among arthropods and their hosts: a systematic review and meta-analysis Instituut voor Tropische Geneeskunde

Carl Gregory Boodman, Johan van Griensven, Wim Van Bortel
Background Bartonella quintana is a body louse-borne bacterium causing bacteremia and infective endocarditis. We aimed to describe B. quintana detection among arthropods and their hosts. Methods We searched databases in PubMed Central/MEDLINE, Scopus, Embase, and Web of Science from January 1, 1915 (the year of B. quintana discovery) to January 1, 2024, to identify publications containing specific search terms relating to B. quintana detection ...

Management of rifampicin-resistant tuberculosis in conflict-affected areas: the case of Iraq Instituut voor Tropische Geneeskunde

HM Tesfahun, L Al-Salihi, NA Al-Ani, AA Mankhi, Alfarazdag Mohammed, CAE Lim, RA Al-Hilfi, Christelle Genevieve Jouego, Tom Decroo, K Moussally, et al.
Since December 2019, the World Health Organization (WHO) has encouraged National Tuberculosis Programs to deprioritize the use of injectable-containing regimens and roll-out all-oral bedaquiline-containing regimens for rifampicin-resistant tuberculosis (RR-TB) treatment. Consequently, Iraq gradually replaced the injectable-containing regimen with an all-oral regimen, including bedaquiline. To assess treatment enrolment and outcomes of both ...

Rabies post-exposure prophylaxis: A retrospective analysis of timing of initiation and antibody responses in a Belgian cohort Instituut voor Tropische Geneeskunde KU Leuven

Matilde Hens, Steven Declercq, Nicole Berens-Riha, Ula Maniewski-Kelner, Caroline Theunissen, Steven Van Den Broucke, Felix De Bièvre, Isabel Brosius, Laurens Liesenborghs, Christophe Van Dijck, et al.
Background
We aimed to determine the timeliness of rabies post-exposure prophylaxis (PEP) and the proportion of individuals with an adequate antibody response post-PEP among those attending the Belgian national reference center.

Methods
Retrospective analysis of patient records who attended our center from 2018 to 2023. Delay was defined as rabies immunoglobulin (RIG) and vaccine initiation beyond 2 calendar days after ...

Expanded prenatal syphilis screening in Manitoba, Canada Instituut voor Tropische Geneeskunde

Carl Gregory Boodman, Jared Bullard, Derek Riley Stein, Santina Lee, Vanessa Poliquin, Paul Van Caeseele

OBJECTIVE: The objective of this study is to provide a direct short-term cost-avoidance analysis of expanded three-time prenatal syphilis screening in the context of Manitoba's ongoing outbreak.

METHODS: A conservative modelling approach increased all financial costs of prenatal screening and minimized the direct costs of congenital syphilis treatment. The cost of syphilis screening was calculated using instrument, reagent and ...