Publicaties

The framework of the Geometrical Product Specification defines the nominal geometry of the components and the characteristic tolerances. Various ISO standards describe the nine defined geometrical properties per characteristic of a workpiece. To prove conformance to the task specific tolerances according ISO 14253–1, the uncertainty budget needs to be determined. This paper presents a digital twin of an optical measurement system as a holistic ...

This study proposes an algorithm to autonomously generate the scan path for a laser line scanner mounted on a coordinate measuring machine. The scan path is determined based on task-specific measurement uncertainty in order to prove conformance to specified tolerances. The novelty of the algorithm is the integration of measurement uncertainty. This development is made possible by recent developments for digital twins of optical measurement ...

Several epidemiological studies have suggested that obesity complicated with insulin resistance and type 2 diabetes exerts deleterious effects on the skeleton. While obesity coexists with estrogen deficiency in postmenopausal women, their combined effects on the skeleton are poorly studied. Thus, we investigated the impact of high-fat diet (HFD) on bone and metabolism of ovariectomized (OVX) female mice (C57BL/6J). OVX or sham operated mice were ...

In cochlear implant surgery, insertion of perimodiolar electrode arrays into the scala tympani can be complicated by trauma or even accidental translocation of the electrode array within the cochlea. In patients with partial hearing loss, cochlear trauma can not only negatively affect implant performance, but also reduce residual hearing function. These events have been related to suboptimal positioning of the cochlear implant electrode array ...

Biological tissues comprise a spatially complex structure, composition and organization at the microscale, named the microstructure. Given the close structure-function relationships in tissues, structural characterization is essential to fully understand the functioning of healthy and pathological tissues, as well as the impact of possible treatments. Here, we present a nondestructive imaging approach to perform quantitative 3D histo(patho)logy ...

OBJECTIVE: The use of thiazolidinediones (TZDs) as insulin sensitizers has been shown to have side effects including increased accumulation of bone marrow adipocytes (BMAds) associated with a higher fracture risk and bone loss. A novel TZD analog MSDC-0602K with low affinity to PPARγ has been developed to reduce adverse effects of TZD therapy. However, the effect of MSDC-0602K on bone phenotype and bone marrow mesenchymal stem cells (BM-MSCs) in ...

High-resolution non-destructive 3D microCT imaging allows the visualization and structural characterization of mineralized cartilage and bone. Deriving statistically relevant quantitative structural information about these tissues, however, requires automated segmentation procedures, mainly because manual contouring is user-biased and time-consuming. Despite the increased spatial resolution in microCT 3D volumes, automatic segmentation of ...

Laser sintering is evolving towards a genuine manufacturing technique for volume production and mass customized products. However, variability in part quality has to be reduced further to enable its use for high demanding and critical end-use applications. High volume and mass customized manufacturing impose the need for a fast and flexible measurement instrument, to automatically assess the overall part quality, which is currently not available ...