Publicaties

The EBMT recommends rabbit anti-thymocyte or anti-T-lymphocyte globulin (rATG/ATLG) as GVHD prophylaxis in matched sibling donor (MSD) allogeneic hematopoietic cell transplantation (allo-HCT). However, discrepancies between recommendations and clinical practice were reflected in the EBMT survey. Therefore, we performed retrospective EBMT registry analysis from 2014 to 2021 to reinforce the real-world evidence context of rATG/ATLG impact on ...

BACKGROUND AND PURPOSE: Adherence to oral anticancer therapy correlates with outcome. Lenalidomide (LEN) is an oral mainstay treatment for multiple myeloma (MM), administered in 21-day/7-day (on/off) cycles. Data on LEN adherence is limited. Electronic monitoring (EM) represents the most reliable adherence assessment method. EXPERIMENTAL APPROACH: We conducted a prospective observational study using electronic medication event monitoring (MEMS®) ...

PURPOSE: Allogeneic hematopoietic stem cell transplantation (AlloHSCT) survivors have complex needs and can benefit from eHealth-facilitated integrated care models (ICM), such as the SMILe-ICM (SteM cell transplantation faciLitated by eHealth) which combines eHealth monitoring and support from an advanced practice nurse (APN). Originally developed in a Swiss/German context, it showed promising outcomes regarding mortality, rehospitalization and ...

Allogeneic hematopoietic cell transplantation (alloHCT) from 8/10 HLA-matched unrelated donor is performed in a minority of patients. There is little data on its outcomes and consequently, guidelines on optimal transplantation procedures are lacking. The Transplant complications working party of the EBMT performed a registry study comparing approaches to graft-versus-host disease (GVHD) prophylaxis in recipients of alloHCT from 8/10 ...

We assessed whether the incidence and outcomes of chronic Graft-versus-Host Disease (cGvHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) have changed over 30 years. We studied 102,275 adults with hematological malignancies receiving a first alloHSCT from identical siblings or unrelated donors. We compared 3 decades: (I) 1990-1999 vs. (II) 2000-2009 vs. (III) 2010-2019. Over time, patients were older at transplantation, ...

BACKGROUND: After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid measurements. The Basel Assessment of Adherence-to Immunosuppressive Medications Scale (BAASIS) is a validated self-report tool to detect non-adherence, however, its ability to predict clinically relevant outcomes remains to be established. METHODS: In this prospective cohort study including 226 ...

BACKGROUND: Cardiovascular (CV) disease represents a leading cause of death in kidney transplant recipients (KTRs). Poor physical fitness adds to the increased CV risk of KTRs. Exercise-based rehabilitation and physical activity interventions may prove pivotal in both short and long-term outcomes after kidney transplantation. METHODS: PHOENIX-Kidney is a prospective, multicentre, randomized, controlled, single-blinded trial with parallel groups. ...

Switzerland invests substantially in research, yet many innovations fail to reach routine healthcare. This paper argues that embedding implementation science into national research infrastructures is key to closing this gap, reducing research waste and accelerating translation into practice. By strengthening initiatives such as IMPACT and national funding programmes, Switzerland can ensure its innovations deliver timely, sustainable benefits for ...

RATIONALE: Nonadherence to routine outpatient appointments (NApp) post kidney transplantation (KT) is a poorly studied health behavior associated with unfavorable outcomes. In the ADHERE BRAZIL Study, we previously reported a high prevalence of this behavior (12.7%). AIMS AND OBJECTIVE: This study aimed to identify the multilevel factors associated with NApp after KT. METHOD: A cross-sectional study, subproject of the ADHERE BRAZIL Study, was ...

BACKGROUND: There is a growing population of hematopoietic cell transplantation (HCT) survivors who later require a solid organ transplant (SOT). However, there are limited data on survival, risk factors (RFs) for SOT graft loss, and death. METHODS: This is a retrospective Center for International Blood and Marrow Transplant Research study that included recipients of HCT followed by SOT between 2001 and 2017. HCT data were merged with data from ...