Publicaties
Creating Pathways to Impact: Investing in Supply Chain and Logistics Capacity Development in Africa KU Leuven
Childhood vaccine supply chains in low- and middle-income countries KU Leuven
Immunization substantially contributes to global health by saving millions of lives every year. Yet, a vast amount of people around the world, including nearly 20 to 25 million infants each year, have insufficient access to vaccines. Challenges related to the storage and distribution of vaccines persist, contributing to vaccination coverage rates that are below the required thresholds to reach herd immunity. Our research is motivated and based ...
A Systems-Based Framework for Immunisation System Design: Six Loops, Three Flows, Two Paradigms KU Leuven
Despite massive progress in vaccine coverage globally, the region of sub-Saharan Africa is lagging behind for Sustainable Development Goal 3 by 2030. Sub-national under-immunisation is part of the problem. In order to reverse the current immunisation system's (IMS) underperformance, a conceptual model is proposed that captures the complexity of IMSs in low- and middle-income countries (LMICs) and offers directions for sustainable redesign. The ...
Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights KU Leuven
Background: HIV drug resistance (HIVDR) continues to threaten the effectiveness of worldwide antiretroviral therapy (ART). Emergence and transmission of HIVDR are driven by several interconnected factors. Though much has been done to uncover factors influencing HIVDR, overall interconnectedness between these factors remains unclear and African policy makers encounter difficulties setting priorities combating HIVDR. By viewing HIVDR as a complex ...
Factors Associated with HIV Drug Resistance in Dar es Salaam, Tanzania: Analysis of a Complex Adaptive System KU Leuven
HIV drug resistance (HIVDR) is a complex problem with multiple interconnected and context dependent causes. Although the factors influencing HIVDR are known and well-studied, HIVDR remains a threat to the effectiveness of antiretroviral therapy. To understand the complexity of HIVDR, a comprehensive, systems approach is needed. Therefore, a local systems map was developed integrating all reported factors influencing HIVDR in the Dar es Salaam ...