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Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome Universiteit Antwerpen
Background: Overall survival (OS) and outcome of cancer patients with bisphosphonate-associated osteonecrosis of the jaw (ONJ) using conservative treatment (chlorhexidine 0.12% rinse, intermittent antibiotics, and careful sequestrectomy) are unknown. Design: In all, 33 ONJ patients were studied for OS and ONJ outcome. Results: Median duration of bisphosphonate treatment was 27 months (range 4115) and was stopped in 25 (76%) patients. Nine (27%) ...
Bisphosphonates in oncology: rising stars or fallen heroes Universiteit Antwerpen
The introduction of bisphosphonates in oncology has dramatically changed the management of patients with metastatic bone disease. In this manuscript, we thoroughly scrutinize the available body of clinical trials supporting the use of bisphosphonates in this setting and review new and ongoing research. Additionally, we summarize the data showing the benefits of bisphosphonate use in the prevention of treatment-induced bone loss and the ...
Chemoradiation interactions under reduced oxygen conditions: cellular characteristics of an **in vitro** model Universiteit Antwerpen
Hypoxic tumour regions often contain viable cells that are more resistant to chemotherapy and/or radiotherapy, making it of key importance to analyse new combination treatments under both normoxic and hypoxic conditions. In this study, the impact of moderate hypoxia and anoxia on cellular characteristics was investigated in isogenic A549 cells differing in p53 status. VEGF expression, doubling time, cell cycle distribution, induction of ...
Feasibility of collecting self-sampled vaginal swabs by mail: quantity and quality of genomic DNA Universiteit Antwerpen
Vaginal self-sampling may be valuable as an alternative method of cervical cancer screening in areas of poor resources, to enrol women who, otherwise, would not participate in population-based cervical cancer screening and in epidemiological follow-up studies. We assessed the reliability of mailed vaginal samples by evaluating the quantity and quality of genomic DNA in the samples. Mailed swabs (n = 201) were compared with freshly collected ...
Recente verbeteringen in de inductiechemotherapie van locoregionaal gevorderde hoofd-halstumoren Universiteit Antwerpen
Treatment strategy in patients with locoregionally advanced head and neck cancer has gradually evolved into one that is based upon radiotherapy and chemotherapy. In this setting, induction chemotherapy with cisplatin and 5-fluorouracil, followed by locoregional treatment with (chemo)-radiotherapy, has proven to be a valuable option.Several randomised trials have shown that the addition of a taxane to the cisplatin/5-fluorouracil-scheme is ...