Publicaties
Efficacy and safety of re-treatment with the same artemisinin-based combination treatment (ACT) compared with an alternative ACT and quinine plus clindamycin after failure of first-line recommended ACT (QUINACT): a bicentre, open-label, phase 3, randomise Instituut voor Tropische Geneeskunde Universiteit Antwerpen
BACKGROUND: Quinine or alternative artemisinin-based combination treatment (ACT) is the recommended rescue treatment for uncomplicated malaria. However, patients are often re-treated with the same ACT though it is unclear whether this is the most suitable approach. We assessed the efficacy and safety of re-treating malaria patients with uncomplicated failures with the same ACT used for the primary episode, compared with other rescue ...
Spatio-temporal analysis of malaria incidence in the Peruvian Amazon Region between 2002 and 2013 Instituut voor Tropische Geneeskunde Universiteit Gent
Malaria remains a major public health problem in the Peruvian Amazon where the persistence of high-risk transmission areas (hotspots) challenges the current malaria control strategies. This study aimed at identifying significant space-time clusters of malaria incidence in Loreto region 2002-2013 and to determine significant changes across years in relation to the control measures applied. Poisson regression and purely temporal, spatial, and ...
Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background: Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country's malaria incidence is highly variable at provincial level, but less is known at village level. This study used passive case detection (PCD) data at village level in Ratanakiri Province from 2010 to 2014 to describe incidence ...
Expression of the Plasmodium falciparum clonally variant clag3 genes in human infections Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background.: Many genes of the malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic level. These genes participate in fundamental host-parasite interactions and contribute to adaptive processes. However, little is known about their expression patterns during human infections. A peculiar case of clonally variant genes are the 2 nearly identical clag3 genes, clag3.1 and clag3.2, which mediate ...
Community participation as part of formative research to design innovative malaria elimination strategies in The Gambia Instituut voor Tropische Geneeskunde
Malaria tropica in Antwerpen Instituut voor Tropische Geneeskunde
Factors associated with non-participation and non-adherence in directly observed mass drug administration for malaria in the Gambia Instituut voor Tropische Geneeskunde Vrije Universiteit Brussel Universiteit Gent
INTRODUCTION: The potential benefits of Mass Drug Administration (MDA) for malaria elimination are being considered in several malaria endemic countries where a decline in malaria transmission has been reported. For this strategy to work, it is important that a large proportion of the target population participates, requiring an in-depth understanding of factors that may affect participation and adherence to MDA programs.
METHODOLOGY: ...