Publicaties
Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated Thrombotic Thrombocytopenic Purpura. KU Leuven
ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome KU Leuven
Optimization of the detection of inhibitory autoantibodies against the VWF-cleaving protease ADAMTS13 with an automated chemiluminescent ADAMTS13 activity immunoassay KU Leuven
Determination of antiU+2010ADAMTS13 autoantibody titers in ELISA : influence of ADAMTS13 presentation and autoantibody detection Universiteit Gent KU Leuven
ADAMTS13 and Non-ADAMTS13 Biomarkers in Immune-Mediated Thrombotic Thrombocytopenic Purpura KU Leuven
ADAMTS13 in health and disease Universiteit Gent KU Leuven
Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13 Vrije Universiteit Brussel KU Leuven
Introduction: Patients suffering from congenital thrombotic thrombocytopenic purpura (cTTP) have a deficiency in ADAMTS13 due to mutations in their ADAMTS13 gene. Objective: The aim of this study was to determine ADAMTS13 parameters (activity, antigen, and mutations), to investigate if the propositus suffered from child-onset cTTP, and to study the in vitro effect of the ADAMTS13 mutations. Methods: ADAMTS13 activity and antigen were ...
Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis Instituut voor Tropische Geneeskunde KU Leuven
BACKGROUND: Previous clinical evidence correlates levels of von Willebrand factor (VWF) and its cleaving protease ADAMTS13 with outcome in septic patients. No previous studies addressed if VWF and ADAMTS13 affected the outcome of Staphylococcus aureus sepsis.
OBJECTIVES: We studied the role of VWF and ADAMTS13 in S. aureus sepsis both in patients and in mice.
METHODS: VWF levels and ADAMTS13 activity levels were measured in ...