Publicaties
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Myxoid hepatocellular adenoma, a rare variant of liver cell adenoma, often clinically misdiagnosed as giant cell haemangioma Universiteit Gent
Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs Universiteit Antwerpen
BackgroundBiomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide study to profile methylation of all three tissue types combined and to identify discriminatory biomarkers.ResultsPublic methylation array data (Illumina EPIC and 450K) were collected from a total of 1 892 colorectal samples. Pairwise ...
Association of parathyroid adenoma and familial hypocalciuric hypercalcaemia in a teenager. Vrije Universiteit Brussel
Objective: Familial hypocalciuric hypercalcaemia (FHH) is clinically characterized by mild to moderate
parathyroid hormone (PTH)-dependent hypercalcaemia, autosomal dominant pattern of inheritance,
and normal to frankly reduced urinary calcium excretion in spite of a high serum calcium (clearance
(Ca)/clearance (Cr)!0.01). FHH has a benign course and should be differentiated from primary
hyperparathyroidism. It is usually ...
parathyroid hormone (PTH)-dependent hypercalcaemia, autosomal dominant pattern of inheritance,
and normal to frankly reduced urinary calcium excretion in spite of a high serum calcium (clearance
(Ca)/clearance (Cr)!0.01). FHH has a benign course and should be differentiated from primary
hyperparathyroidism. It is usually ...
Parathyroid adenoma mimicking a malignant lymph node on F-18-choline PET-CT Universiteit Gent
Prostate carcinoma is the most common cancer in men. After local therapy, disease recurs in many patients. A choline PET/CT is indicated in case of biochemical relapse of prostate carcinoma to determine the site of recurrence (local and/or distant) and to help select the next line of therapy. Choline PET-CT is also known to show an elevated uptake in hyperfunctioning parathyroid adenoma. This case report shows the difficulty to distinguish ...
Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression Universiteit Gent
Objective: This study aimed to identify the oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on mRNA expression of genes in this amplicon.Methods: Segmentation of DNA copy number changes on 20q was performed by array CGH (comparative genomic hybridisation) in 34 non-progressed colorectal adenomas, 41 progressed adenomas (ie, adenomas that present a focus of cancer) and 33 ...
The association of astrocytoma and pituitary adenoma in a patient with alcaptonuria Instituut voor Tropische Geneeskunde
Ectopic sphenoidal ACTH-secreting adenoma revealed by ¹¹C Methionine PET scan Universiteit Antwerpen
BackgroundEctopic ACTH pituitary adenomas (EAPA), located outside the sella turcica and deriving from cellular remnants of Rathke's pouch are a very rare cause of Cushing's syndrome (CS). The diagnosis is often difficult and delayed, even after comprehensive work-up. To our knowledge, we report for the first time an ectopic corticotroph tumor of the posterior wall of the sphenoid sinus, leading to false positive results of bilateral inferior ...
Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas KU Leuven
We retrospectively evaluated how accurately preoperative imaging localizes parathyroid adenoma in superior versus inferior parathyroids. Over 6 years, 104 patients with primary hyperparathyroidism underwent parathyroid surgery in a single centre. Of these, 103 underwent ultrasound, 97 [99mTc]pertechnetate/MIBI SPECT/CT and 30 [18F]fluorocholine (FCH) PET/CT. One patient with a unilateral double adenoma was excluded from the analysis. Surgical ...
4DCT Differentiation of Parathyroid Adenoma Vrije Universiteit Brussel
UNLABELLED: We report the case of a 72-year-old patient presenting with recurrent primary hyperparathyroidism after total thyroidectomy and parathyroidectomy with presternal autotransplantation. Methionine-PET-CT proved false-positive and Tc-99m-tetrofosmine imaging false-negative. Using a novel multiphase-4DCT technique we identified an anterior mediastinal nodule demonstrating contrast wash-in and wash-out, suggesting parathyroid adenoma. ...