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The Effect of Nitrate-Rich Beetroot Juice on Markers of Exercise-Induced Muscle Damage Vrije Universiteit Brussel

Louise Jones, Stephen Bailey, Samantha N Rowland, Nehal Alsharif, Oliver M Shannon, Tom Clifford

This systematic review and meta-analysis of randomized controlled trials examined whether dietary nitrate supplementation attenuates exercise-induced muscle damage (EIMD) and is reported according to the PRISMA guidelines. Medline and SPORTDiscus databases were searched from inception to June 2020. Inclusion criteria were studies in adult humans consuming inorganic nitrate before and after exercise and that measured markers implicated in the ...

Counteracting lower-limb muscle dysfunction in patients with COPD Universiteit Gent

Jana De Brandt
1. Introduction to chronic obstructive pulmonary disease (COPD) 1.1. Definition and diagnosis of COPD According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD)guidelines “chronic obstructive pulmonary disease (COPD) is a common,preventable and treatable disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious ...

Critical appraisal of the oxidative stress pathway in vitiligo : a systematic review and meta-analysis Universiteit Gent

Reinhart Speeckaert, J Dugardin, Jo Lambert, Hilde Lapeere, Evelien Verhaeghe, Marijn Speeckaert, Nanja van Geel
Background: The pathogenesis of vitiligo remains a topic of extensive debate. This is partly due to the moderate efficacy of current treatments. The role of the oxidative stress pathway in vitiligo is a popular although controversial research topic. Objective: To clarify the role of the oxidative stress pathway in vitiligo compared to other inflammatory skin disorders and to assess the therapeutic role of antioxidants. Methods: We conducted a ...

Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors Universiteit Gent Universiteit Antwerpen Vlaams Instituut voor Biotechnologie

Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz Hassannia, Tom Vanden Berghe, Koen Augustyns
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential. Although, novel biochemical ...

The pharmacokinetics of gallic acid in finisher broilers Instituut voor Landbouw-, Visserij- en Voedingsonderzoek

Kobe Buyse, Evelyne Delezie, L. Goethals, Noémie Van Noten, Christof Van Poucke, M. Devreese, G Antonissen, G.P.J. Janssens, Marta Lourenço Ribeiro Alves
The current challenges in broiler production require the use of additives in the feed with an increased usage of natural plant extracts. Among others, tannins show potential as antioxidants, metal chelators and antimicrobial compound. Gallic acid is a building block of hydrolysable tannins to which most of the tannin properties could be linked. Despite its increasing use, little is known on the bioavailability of this compound. Therefore, a ...

Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice KU Leuven Universiteit Gent

Melissa Swinnen, Jozef Bartunek, Stefan Janssens
AIMS: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity. RESULTS: Doxorubicin administration (20 mg/kg, intraperitoneally [IP]) reduced cardiac sGC activity in wild-type (WT) mice. To investigate whether decreased sGC activity contributes to ...

Biocontrol of Fusarium wilt disease in pepper plant by plant growth promoting Penicillium expansum and Trichoderma harzianum Universiteit Antwerpen

Amer M. Abdelaziz, Mohmed H. Sharaf, Amr H. Hashem, Abdulaziz A. Al-Askar, Samy A. Marey, Fares A. Mohamed, Mohamed N. Abdelstar, Mosad A. Zaki, Hamada Abd Elgawad, Mohamed S. Attia, et al.
Plant growth promoting fungi (PGPF) were employed in the present study to biocontrol Fusarium wilt disease in pepper plants. Two of the five fungal isolates were chosen based on biochemical characteristics such as their production of hydrocyanic acid, siderophores, and IAA, phosphate solubilization, and in vitro antifungal activities. The most potent fungal isolates were identified as Penicillium expansum (P. expansum) and Trichoderma harzianum ...

Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity KU Leuven

Mathy Froeyen, Muhammad Usman Mirza
Cisplatin is amongst the most potent chemotherapeutic drugs with applications in more than 50% of cancer treatments, but dose-dependent side effects limit its usefulness. Berberis vulgaris L. (B. vulgaris) has a proven role in several therapeutic applications in the traditional medicinal system. High-performance liquid chromatography was used to quantify berberine, a potent alkaloid in the methanolic root extract of B. vulgaris (BvRE). Berberine ...