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Biotin interferences Vrije Universiteit Brussel

Jean-Louis Bayart, Julien Favresse, Anke Stoefs, Mélanie Closset, Tatiana Roy, Catherine Fillée, Hector Rodriguez-Villalobos, Damien Gruson

BACKGROUND: Biotin has been reported to be a leading cause of interference on several immunoassay platforms using the streptavidin-biotin immobilization system. While biotin interferences have now been well characterized for several assays, only few data are available on their impact on serological markers of infectious viral diseases.

METHODS: Overall, 10 healthy volunteers (HVs) received a single 100 mg dose of biotin to evaluate ...

Nanobody-coupled microbubbles as novel molecular tracer Vrije Universiteit Brussel

Sophie Hernot, Sunil Unnikrishnan, Zhongmin Du, Talent Shevchenko, Bernard Cosyns, Alexis Broisat, Jakub Toczek, Vicky Caveliers, Serge Muyldermans, Tony Lahoutte, et al.

Camelid-derived single-domain antibody-fragments (~15kDa), called nanobodies, are a new class of molecular tracers that are routinely identified with nanomolar affinity for their target and that are easily tailored for molecular imaging and drug delivery applications. We hypothesized that they are well-suited for the design of targeted microbubbles (μBs) and aimed to develop and characterize eGFP- and VCAM-1-targeted μBs. Anti-eGFP (cAbGFP4) ...