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Hexasodium fytate (SNF472 or CSL525) inhibits ectopic calcification in various pseudoxanthoma elasticum and calcinosis cutis animal models Universiteit Gent

Miguel D. Ferrer, Maria del Mar Perez-Ferrer, Marc Blasco, Ida Joely Jacobs, Qiaoli Li, Olivier Vanakker, Lisa Dangreau, Andrea Lopez, Gianluca Malagraba, Firas Bassissi, et al.
Background/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals. Hexasodium fytate (CSL525, previously known as SNF472) is a crystallization inhibitor being developed for the treatment of ectopic calcification-related disorders. Our aim was to investigate CSL525 for the treatment of soft-tissue calcification disorders in animal models ...

Idiopathic tumoral calcinosis Universiteit Antwerpen Universiteit Gent

Teaching Point: The imaging clues to differentiate idiopathic tumoral calcinosis from other calcified soft tissue lesions include: pseudotumoral appearance with mass effect, bone erosion with intra-osseous protrusion of calcification, lobulated morphology, and peri-articular location on the extensor side.

From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders Universiteit Gent

Eva De Vilder, Olivier Vanakker
Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality. Further, pathologic mineralization is seen in several rare genetic disorders, which often present life-threatening phenotypes. These disorders are classified based on the mechanisms through which the mineralization occurs: ...

Focus on echovascular imaging assessment of arterial disease Vrije Universiteit Brussel

Muriel Sprynger, Fausto Rigo, Marie Moonen, Thor Edvardsen, Monica L de Alcantara, Katerina K Naka, Serge Kownator, Iana Simova

The main goal of the present document is to provide a set of practical recommendations for ultrasound imagers who are interested in artery diseases or for physicians who intend to undertake vascular procedures. This is the first part of the work. It is dedicated to general principles of ultrasonography, cervicoencephalic, subclavian, aortoiliac and lower extremity arteries, abdominal aorta, and popliteal aneurysms. It also discusses ...

Comparison of the Quantity of Calcium in the Aortic Valve and the Coronary Arteries in Men Versus Women Who Underwent Transcatheter Aortic Valve Implantation Universiteit Hasselt

Jan STASSEN
Several studies have shown an association between aortic stenosis (AS) and coronary atherosclerosis. This study aimed to evaluate the gender differences in aortic valve calcium (AVC) and coronary artery calcium (CAC) and the association between CAC and allcause mortality in patients with severe AS. A total of 260 patients (80 7 years, 39% men) with severe AS who were scheduled for transcatheter aortic valve implantation (TAVI) were included. AVC ...

Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats Vrije Universiteit Brussel

Gezim Bala, Kris Gillis, Isabel Remory, Joan Somja, Eléonore Delvenne, Joeri De Nayer, Johan Schiettecatte, Philippe Delvenne, Patrizio Lancellotti, Guy Van Camp, et al.

BACKGROUND: Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology.

METHODS: 28 male Wistar rats ...

Osteosarcoma with extensive calcified pleural metastases at diagnosis Vrije Universiteit Brussel Universiteit Gent

N. Verbeke, K Verstraete, G Sys, Ramses Forsyth, D Kluyskens, H. Denys, Dirk Uyttendaele, S Rottey

We report the case of an 18 year old woman presenting with shortness of breath and pain in the left shoulder. Imaging of the lungs revealed pleural effusion and calcification of the left pleura. An osteosarcoma of the left humerus was the final diagnosis. A review of the literature reveals that calcified pleural metastatic disease in cases of osteosarcoma has been infrequently reported. Other causes of pleural calcification are briefly ...

Kangaroo vs. porcine aortic valves Vrije Universiteit Brussel

Kishan Narine, Cyrille C Chéry, Els Goetghebeur, Ramses Forsyth, E Claeys, Maria Cornelissen, L Moens, G Van Nooten

The aim of this study was to evaluate and compare the calcification potential of kangaroo and porcine aortic valves after glutaraldehyde fixation at both low (0.6%) and high (2.0%) concentrations of glutaraldehyde in the rat subcutaneous model. To our knowledge this is the first report comparing the time-related, progressive calcification of these two species in the rat subcutaneous model. Twenty-two Sprague-Dawley rats were each implanted ...