Publicaties
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Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-beta-L-arabinose and its immunomodulatory potential Universiteit Gent
Modification of the Lipid A phosphates by positively charged appendages is a part of the survival strategy of numerous opportunistic Gram-negative bacteria. The phosphate groups of the cystic fibrosis adapted Burkholderia Lipid A are abundantly esterified by 4-amino-4-deoxy-beta-L-arabinose (beta-L-Ara4N), which imposes resistance to antibiotic treatment and contributes to bacterial virulence. To establish structural features accounting for the ...
Titanium oxide nanoparticles and low temperature thin film synthesis by chemical solution deposition for photocatalytic applications Universiteit Gent
Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications Universiteit Gent
t-Boc Synthesis of Huwentoxin-I Through Native Chemical Ligation Incorporating a Trifluoromethanesulfonic Acid Cleavage Strategy KU Leuven
Tert-butyloxycarbonyl (t-Boc)-based native chemical ligation (NCL) techniques commonly employ hydrogen fluoride (HF) to create the thioester fragment required for the ligation process. Our research aimed to assess the replacement of HF with Trifluoromethanesulfonic acid (TFMSA). Here we examined a 33 amino acid test peptide, Huwentoxin-I (HwTx-I) as a novel candidate for our TFMSA cleavage protocol. Structurally HwTx-I has an X-Cys(16) -Cys(17) ...
Advancing chemical sensors synthesis and classification for the integration of mems optical phased array in polymer nanocomposites Universiteit Antwerpen
This study focuses on the advancement of chemical sensor synthesis and classification techniques to enable the seamless integration of Micro-Electro-Mechanical Systems (MEMS) optical phased arrays within polymer nanocomposites. The integration of MEMS optical phased arrays holds immense potential for applications in real-time chemical sensing and imaging. In this research, we present a comprehensive approach to fabricating polymer nanocomposites ...
Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1 KU Leuven Universiteit Gent
Phlotoxin-1 (PhlTx1) is a peptide previously identified in tarantula venom (Phlogius species) that belongs to the inhibitory cysteine-knot (ICK) toxin family. Like many ICK-based spider toxins, the synthesis of PhlTx1 appears particularly challenging, mostly for obtaining appropriate folding and concomitant suitable disulfide bridge formation. Herein, we describe a procedure for the chemical synthesis and the directed sequential disulfide bridge ...