Publicaties
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Crystal Growth Kinetics of an Industrial Active Pharmaceutical Ingredient: Implications of Different Representations of Supersaturation and Simultaneous Growth Mechanisms KU Leuven
The crystal growth kinetics of a proprietary active pharmaceutical ingredient (API) was investigated by isothermal seeded batch de-supersaturation experiments in solvent mixtures using the “true” thermodynamic representation of the supersaturation driving force, which considers the activities of the saturated and supersaturated states. Three approaches to approximate the experimentally inaccessible activity coefficients of the supersaturated ...
Comparison of different experimental techniques for the measurement of crystal growth kinetics Vrije Universiteit Brussel
The relative merits and domains of application of three observation techniques (atomic force microscopy, Michelson
interferometry, and laser confocal microscopy with differential interference contrast microscopy) for the investigation of crystal
growth kinetics are discussed in the context of protein crystallization. Growth rate measurements on the same system under identical
experimental conditions using different techniques ...
interferometry, and laser confocal microscopy with differential interference contrast microscopy) for the investigation of crystal
growth kinetics are discussed in the context of protein crystallization. Growth rate measurements on the same system under identical
experimental conditions using different techniques ...
On the Self-Purification Cascade during Crystal Growth from Solution Vrije Universiteit Brussel
We report on the failure of the Cabrera-Vermilyea (CV) step pinning model to reproduce the elementary step kinetics for the case of tetragonal lysozyme crystals growing from contaminated solutions. We measured the supersaturation dependency of the step velocity using confocal microscopy for three different commercially available lysozyme batches with varying levels of impurity content, that is, Seikagaku, Fluka, and Sigma. Strong nonlinear ...
Formation energy of intrinsic point defects in nanometer-thick Si and Ge foils and implications for Ge crystal growth from a melt Universiteit Gent
On the impact of stress on intrinsic defect formation during single crystal silicon growth Universiteit Gent
Crystal Growth Cessation Revisited: The Physical Basis of Step Pinning Vrije Universiteit Brussel
The growth of crystals from solution is a fundamental process of relevance to such diverse areas as X-ray diffraction structural determination and the role of mineralization in living organisms. A key factor determining the dynamics of crystallization is the effect of impurities on step growth. For over 50 years, all discussions of impurity-step interaction have been framed in the context of the Cabrera-Vermilyea (CV) model for step blocking, ...
Si crystal growth from a melt: the secrets behind the v/G criterion Universiteit Gent
The so called vIG criterion defines a critical value of the ratio of the pulling rate v over the thermal gradient G at the melt solid interface. For a ratio larger than this critical value, the crystal is vacancy-rich while for values below the critical value, the crystal is interstitial-rich. When the ratio is equal to the critical value, the crystal would be defect free or made of "perfect silicon". The expression for the critical ratio is ...
An integrated crystal plasticity-phase field model for spatially resolved twin nucleation, propagation, and growth in hexagonal materials KU Leuven
© 2018 Elsevier Ltd. Typical hexagonal engineering materials, such as magnesium and titanium, deform extensively through shear strains and crystallographic re-orientations associated with the nucleation, propagation, and growth of twins. To accurately predict their deformation behavior it is, therefore, critical for constitutive models to incorporate these mechanisms. In this work an integrated approach for modeling the concurrent dislocation ...