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pH-Triggered Controlled Release of Chlorhexidine Using Chitosan-Coated Titanium Silica Composite for Dental Infection Prevention KU Leuven
Peri-implantitis is a growing pathological concern for dental implants which aggravates the occurrence of revision surgeries. This increases the burden on both hospitals and the patients themselves. Research is now focused on the development of materials and accompanying implants designed to resist biofilm formation. To enhance this endeavor, a smart method of biofilm inhibition coupled with limiting toxicity to the host cells is crucial. ...
Experimental tricalcium silicate cement induces reparative dentinogenesis KU Leuven
OBJECTIVES: To overcome shortcomings of hydraulic calcium-silicate cements (hCSCs), an experimental tricalcium silicate (TCS) cement, named 'TCS 50', was developed. In vitro research showed that TCS 50 played no negative effect on the viability and proliferation of human dental pulp cells, and it induced cell odontogenic differentiation. The objective was to evaluate the pulpal repair potential of TCS 50 applied onto exposed minipig pulps. ...
Implant functionalization with mesoporous silica: A promising antibacterial strategy, but does such an implant osseointegrate? KU Leuven Vlaams Instituut voor Biotechnologie
Objectives: New strategies for implant surface functionalization in the prevention of peri-implantitis while not compromising osseointegration are currently explored. The aim of this in vivo study was to assess the osseointegration of a titanium-silica composite implant, previously shown to enable controlled release of therapeutic concentrations of chlorhexidine, in the Göttingen mini-pig oral model. Material and methods: Three implant groups ...
Dental Implant Macro-Design Features Can Impact the Dynamics of Osseointegration KU Leuven
PURPOSE: The purpose of this study was to compare the clinical performance of two dental implant types possessing a different macro-design in the in vivo pig model. MATERIALS AND METHODS: Titanium AadvaTM implants (GC, Tokyo, Japan) were compared with OsseoSpeedTM implants (Astra, Mölndal, Sweden), with the Aadva implant displaying significant larger inter-thread dimensions than the OsseoSpeed implant. Implants were installed in the parietal ...
Oral Implant Restorations by Undergraduate Students: Clinical Outcomes of up to 5 Years KU Leuven
PURPOSE: To clinically evaluate oral implant restorations placed by undergraduate students in the dental clinical curriculum at KU Leuven (Belgium) in terms of function and esthetics. MATERIALS AND METHODS: A retrospective observational cohort study was designed. The esthetic and functional evaluations of implant-supported restorations placed in the framework of the undergraduate implant dentistry clinical training program using White/Pink ...
TOWARDS IMPROVED DENTAL BONDING USING UNIVERSAL ADHESIVES KU Leuven
The overall PhD-project aim is to explore the bonding mechanisms of the newest generation of universal adhesives as well as to research new ways to improve bonding effectiveness and bond durability of universal adhesives to both tooth tissue and glass-rich ceramics.
Ultrastructural characterization of the implant interface response to loading KU Leuven
Dynamic loading can affect the bone surrounding implants. For ultrastructural exploration of the peri-implant tissue response to dynamic loading, titanium implants were installed in rat tibiae, in which one implant was loaded while the contralateral served as the unloaded control. The loaded implants received stimulation either within 24 hrs after implantation (immediate loading) or after a 28-day healing period (delayed loading) for 4, 7, 14, ...
Towards an improved dental pulp-capping therapy KU Leuven
SUMMARY.A recent Delphi survey on the future of restorative dentistry for the next 20 years identified maintenance of the pulp vitality as of the highest importance [1]. The authors rated bioactivity toward the pulp-dentin complex as key property for future tooth-restorative materials. This need to develop bioactive restorative materials was also the conclusion drawn on a workshop ('Future innovation and research in dental restorative ...
Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure KU Leuven
Biological tissues have a complex and heterogeneous 3D structure, which is only partially revealed by standard histomorphometry in 2D. We here present a novel chemical compound for contrast-enhanced microfocus computed tomography (CE-CT), a Hafnium-based Wells-Dawson polyoxometalate (Hf-POM), which allows simultaneous 3D visualization of mineralized and non-mineralized skeletal tissues, such as mineralized bone and bone marrow vasculature and ...