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The role of VEGF in paclitaxel - induced peripheral neuropathy KU Leuven

An Verheyen
The vascular endothelial growth factor (VEGF) was originally purified as a growth factor, capable of increasing vascular permeability and endothelial cell proliferation. In recent years, more pluripotent activities of VEGF have been shown, in particular also in the nervous system. Both in vitro and in vivo evidence for a direct protective role of VEGF has been accumulating, with the most convincing evidence coming from studies showing that ...

Management of the cardiorenal syndrome in decompensated heart failure Vrije Universiteit Brussel Universiteit Hasselt

Lars Grieten

BACKGROUND: The management of the cardiorenal syndrome (CRS) in decompensated heart failure (HF) is challenging, with high-quality evidence lacking.

SUMMARY: The pathophysiology of CRS in decompensated HF is complex, with glomerular filtration rate (GFR) and urine output representing different aspects of kidney function. GFR depends on structural factors (number of functional nephrons and integrity of the glomerular membrane) versus ...

Management of the Cardiorenal Syndrome in Decompensated Heart Failure Universiteit Hasselt

Frederik VERBRUGGE, Lars GRIETEN, Wilfried MULLENS
Background: The management of the cardiorenal syndrome (CRS) in decompensated heart failure (HF) is challenging, with high-quality evidence lacking. Summary: The pathophysiology of CRS in decompensated HF is complex, with glomerular filtration rate (GFR) and urine output representing different aspects of kidney function. GFR depends on structural factors (number of functional nephrons and integrity of the glomerular membrane) versus hemodynamic ...

A novel heterozygous likely pathogenic SLC5A2 variant in a diabetic patient with glucosuria and aminoaciduria Vrije Universiteit Brussel

Saohoine Inthasot, Julien Vanderhulst, Peter Janssens, Sien Van Daele, Evelien Van Hoof, Laura Iconaru, Jeroen de Filette

SUMMARY: Familial renal glucosuria (FRG) is a rare renal tubular disorder characterized by increased urinary glucose excretion despite normoglycemia. It is most commonly caused by pathogenic variants in the solute carrier family V member 2 (SLC5A2) gene. This gene encodes the sodium-glucose cotransporter 2, crucial for glucose reabsorption. We report the case of a 44-year-old male referred to the endocrinology outpatient clinic for ...

IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer Universiteit Gent Vlaams Instituut voor Biotechnologie

Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, et al.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between innate and adaptive immune cells. Here, we combine unbiased analysis of blood and tumors from metastatic breast cancer patients treated with ICB with mechanistic studies in mouse models of breast ...

Towards a functional cure of HIV-1: insight in the chromatin landscape of the provirus KU Leuven

Julie Janssens, Anne Bruggemans, Frauke Christ, Zeger Debyser
Despite potent combination antiretroviral therapy, HIV-1 infection persists due to irreversible integration of the virus in long-living cells of the immune system. The main focus of HIV-1 cure strategies has been on HIV-1 eradication, yet without great success so far. Therefore, HIV-1 remission or a functional cure, whereby the virus is silenced rather than eradicated, is considered as an alternative strategy. Elite controllers, individuals who ...

A Systematic Review of the Influence of Continuous Positive Airway Pressure on Fetal and Newborn Animal Models: Suggestions to Improve Neonatal Respiratory Care KU Leuven

André Gie, Yannick Regin, Thomas Salaets, Jan Deprest, Jaan Toelen
INTRODUCTION: Prematurely born infants regularly develop respiratory distress syndrome and require assisted ventilation. Ventilation may injure the premature lung and increase the risk of bronchopulmonary dysplasia. Continuous positive airway pressure (CPAP), a form of noninvasive ventilation, is commonly used in modern neonatology. Limited clinical data are available on the acute and long-term effect of neonatal exposure to CPAP on the lung. ...

Baboon envelope pseudotyped “Nanoblades” carrying Cas9/gRNA complexes allow efficient genome editing in Human T, B, and CD34+ cells and knock-in of AAV6-encoded donor DNA in CD34+ cells KU Leuven

Simone Giovannozzi, Rik Gijsbers
Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into human blood cells can be challenging. Here, we have utilized "nanoblades," a new technology that delivers a genomic cleaving agent into cells. These are modified murine leukemia virus (MLV) or HIV-derived virus-like particle (VLP), in which the viral structural protein Gag has been fused to Cas9. ...

Suppression of epithelial to mesenchymal transitioning (EMT) enhances ex vivo reprogramming of human exocrine pancreatic tissue towards functional insulin producing β-like cells Vrije Universiteit Brussel

Maria Joao Lima, Kenneth Muir, Hilary Docherty, Robert Drummond, Neil Mcgowan, Shareen Forbes, Yves Heremans, I Houbracken, James Ross, Philippe Ravassard, et al.
Due to the lack of tissue available for islet transplantation, new sources of beta-cells have been sought for the treatment of type 1 diabetes. The aim of this study was to determine whether the human exocrid fraction from the islet isolation procedure could be reprogrammed to provide additional islet tissue for transplantation. The exocrine enriched cells rapidly dedifferentiated in culture and grew as a mesenchymal monolayer. Genetic lineage ...

Where does the interplay between cholesterol absorption and synthesis in the context of statin and/or ezetimibe treatment stand today? Vrije Universiteit Brussel

Olivier Descamps, Johan De Sutter, M. Guillaume, L. Missault
The evidence of the different concepts underlying the interplay between cholesterol absorption and synthesis in the context of statin and ezetimibe treatment were reviewed in the light of the eight major trials where cholesterol absorption and synthesis were analyzed on a large scale using the plasma levels of precursors of cholesterol and plant sterols. The only concept supported in all studies is a significant and consistent increase of ...