Publicaties
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Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation Vrije Universiteit Brussel
Liver toxicity observed during (pre)clinical studies is often a major reason for stopping the development of promising drug candidates. Therefore, the pharmaceutical industry is strongly interested in establishing in vitro screening models to detect hepatotoxicity, and especially chronic liver toxicity, early in the drug development process. However, the currently available liver-based in vitro models suffer from phenotypic instability that ...
Neuroblastoma epigenetics : from candidate gene approaches to genome-wide screenings Universiteit Gent
Epigenetics and its implications for ecotoxicology Universiteit Gent
Epigenetics is implicated in the basis of gender incongruence : an epigenome-wide association analysis Universiteit Gent
Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition 2 3 Universiteit Hasselt
Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and ...
Can epigenetics translate environmental cues into phenotypes? Universiteit Gent
Epigenetics in an ecotoxicological context Universiteit Gent
Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption KU Leuven
Epigenetic modifications are responsible for finetuning gene expression profiles to the needs of cells, tissues, and organisms. To rapidly respond to environmental changes, the activity of chromatin modifiers critically depends on the concentration of a handful of metabolites that act as substrates and co-factors. In this way, these enzymes act as metabolic sensors that directly link gene expression to metabolic states. Although metabolites can ...
When environment meets genetics: the role of epigenetics in patients with chronic fatigue syndrome and fibromyalgia KU Leuven
Chronic pain is a debilitating condition for the individual and a huge burden for health societies all over the world. Chronic pain costs more than 600 billion dollars annually in the US, more than cancer, diabetes and heart diseases; and accounts for over 20% of healthcare expenditures in Europe. These data strongly highlight the need of an effective approach, that would improve the understanding and management of chronic pain. It is now well ...