Publicaties
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On epigenetics and telomeres and how 'environmental' factors contribute to the long-term legacy of pediatric critical illness KU Leuven
Critically ill patients are patients who, due to a variety of triggering medical conditions, require vital organ support to avoid imminent death. Despite major progress in intensive care the patients still face a high mortality risk. Moreover, critical illness is hallmarked by features of accelerated aging where many patients experience an adverse legacy of the illness long after hospital discharge. This is mostly described for adults and ...
Epigenetics and transgenerational effects of toxic stress in the water flea Daphnia magna Universiteit Gent
Epigenetics is the study of mitotically or meiotically heritable changes in gene function that occur without a change in the DNA sequence. Epigenetic changes can be triggered by environmental factors and associated changes in gene expression often lead to phenotypic modifications. Epigenetic alterations can sometimes be transferred to subsequent generations, even when the external factor which induced the epigenetic change is no longer present ...
Flowering under enhanced ionising radiation conditions and its regulation through epigenetic mechanisms Universiteit Hasselt
As sessile organisms, plants have to deal with unfavourable conditions by acclimating or adapting in order to survive. Regulation of flower induction is one such mechanism to ensure reproduction and species survival. Flowering is a tightly regulated process under the control of a network of genes, which can be affected by environmental cues and stress. The effects of ionising radiation (IR) on flowering, however, have been poorly studied. ...
Perspectives and challenges of epigenetic determinants of childhood obesity: A systematic review Universiteit Hasselt KU Leuven
The tremendous increase in childhood obesity prevalence over the last few decades cannot merely be explained by genetics and evolutionary changes in the genome, implying that gene-environment interactions, such as epigenetic modifications, likely play a major role. This systematic review aims to summarize the evidence of the association between epigenetics and childhood obesity. A literature search was performed via PubMed and Scopus engines ...
Insights into the interactions between rice and root-knot nematodes from an epigenetic perspective Universiteit Gent
Non-mammalian model organisms in epigenetic research : an overview Universiteit Gent
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation. Unlike genetics, a study of phenotype development as a result of genotypic diversity, epigenetics studies the emergence of (possibly heritable) phenotypic assortment from one DNA sequence. Epigenetic modifications (i.e., DNA methylation, histone tail ...
Epigenetic and miRNA expression changes in people with pain Vrije Universiteit Brussel
Accumulating evidence suggests that epigenetic mechanisms may hold great potential in the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms in people with pain. Four databases have been interrogated: MEDLINE, The Cochrane Central Register of Controlled Trial, Scopus, and Web of Science, following PRISMA guidelines in conducting study selection and assessment. Thirty-seven studies were included. Studies ...
Phloroglucinol treatment induces transgenerational epigenetic inherited resistance against Vibrio infections and thermal stress in a brine shrimp (Artemia franciscana) model Universiteit Gent
Emerging, infectious diseases in shrimp like acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus and mortality caused by other Vibrio species such as Vibrio harveyi are worldwide related to huge economic losses in industrial shrimp production. As a strategy to prevent disease outbreaks, a plant-based phenolic compound could be used as a biocontrol agent. Here, using the brine shrimp (Artemia franciscana) as a model ...
From OPC to Oligodendrocyte: An Epigenetic Journey Universiteit Hasselt
Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering them key players in the functioning of the central nervous system. Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into mature and myelinating cells is a multistep process, tightly controlled by spatiotemporal activation and repression of specific growth and transcription factors. ...