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Conservation genetics of an endemic from the Mediterranean Basin: high genetic differentiation but no genetic diversity loss from the last populations of the Sicilian Grape Hyacinth Leopoldia gussonei Instituut voor Landbouw-, Visserij- en Voedingsonderzoek Universiteit Gent KU Leuven
The Mediterranean Basin is a biodiversity hotspot, housing[11.000 narrowly endemic plant species, many of which are declining due to mass tourism and
agricultural intensification. To investigate the genetic resource impacts of ongoing habitat loss and degradation, we characterized the genetic variation in the last known populations of Leopoldia gussonei, a self-compatible endangered Sicilian Grape Hyacinth numbering less than 3,000 ...
Gene Prioritization Through Genomic Data Fusion: Methods and Applications in Human Genetics (Gen prioritizatie via genomische data fusie: Methodes en toepassingen in menselijke genetica) KU Leuven
Unravelling the molecular basis underlying genetic disorders is crucial in order to develop effective treatments to tackle these diseases. For many years, scientists have explored which genetic factors were associated with several human traits and diseases. After the completion of the human genome project, several high-throughput technologies have been designed and widely used, therefore producing large amounts of genomic data. At the same time, ...
Veterinarians’ competence in applying basic genetic principles and daily implementation of clinical genetics : a study in a university environment Universiteit Gent
Veterinarian competency in genetics is vital for a meaningful application of the rapidly growing number of genetic tests available for animals. We evaluated the use of genetic tests in the daily veterinary practice and the competency of university-employed veterinarians in applying basic principles of genetics in a clinical setting through an electronic survey with 14 cases and 7 statements on genetics. Ninety-one non-geneticist veterinarians ...
High-dimensional Bayesian network inference from systems genetics data using genetic node ordering Universiteit Gent
Studying the impact of genetic variation on gene regulatory networks is essential to understand the biological mechanisms by which genetic variation causes variation in phenotypes. Bayesian networks provide an elegant statistical approach for multi-trait genetic mapping and modelling causal trait relationships. However, inferring Bayesian gene networks from high-dimensional genetics and genomics data is challenging, because the number of ...
Public views on genetics and genetic testing : a survey of the general public in Belgium Universiteit Gent KU Leuven
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology Instituut voor Tropische Geneeskunde
Genetics in everyday life. A qualitative study of individuals at risk of hereditary breast and ovarian cancer (BRCA) and Huntington’s disease (HD) about fears of genetic discrimination KU Leuven
For decades, as our understanding of human genetics has continued to advance, socio-ethical and legal scholars have raised questions and concerns about the ethical and social implications (ELSI issues) of genetics. One specific ELSI concern is that increased knowledge and applications of human genetics might lead to new forms of negative treatment, discrimination, and stigmatisation. In the nineties, several Western countries responded to this ...
Human Genetics Society of Australasia Position Statement: Predictive and Presymptomatic Genetic Testing in Adults and Children. KU Leuven
This Position Statement provides guidelines for health professionals who work with individuals and families seeking predictive genetic testing and laboratory staff conducting the tests. It presents the major practical, psychosocial and ethical considerations associated with presymptomatic and predictive genetic testing in adults who have the capacity to make a decision, children and young people who lack capacity, and adults living with reduced ...