Cellular reprogramming Universiteit Gent
DNA-methylation is an epigenetic modification. These modifications of the DNA do not change the genetic sequence itself, but affect the level ‘above’ it: chemical modifications of the DNA or the histones (where the DNA is wound around) are added or altered. DNA-methylation is the modification where a methyl group is added on cytosine (C) residues in CG dinucleotides. If this takes place in the so-called CpG islands (where CG dinucleotides occur ...