G beta gamma complex antibodies and uses thereof Vlaams Instituut voor Biotechnologie
The present invention relates to antibodies or antibody fragments specifically binding to G beta gamma dimers and uses thereof. More specifically, immunoglobulin single variable domain antibodies causing a GPCR-independent shift in the equilibrium of heterotrimeric G proteins towards dissociated G alpha and antibody-bound G beta gamma subunits were identified. The invention discloses antibodies and active antibody fragments inhibiting G beta gamma signaling, without affecting G alpha, and outcompeting other G beta gamma-regulatory proteins/ effectors, thereby targeting an epitope of G beta ...