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Accelerated HF‐rTMS modifies SERT availability in the subgenual anterior cingulate cortex : a canine [11C]DASB study on the serotonergic system Universiteit Gent Vrije Universiteit Brussel

Yangfeng Xu, Mitchel Kappen, Kathelijne Peremans, Dimitri De Bundel, Ann Van Eeckhout, Nick Van Laeken, Filip De Vos, Jimmy Saunders, Chris Baeken
Repetitive transcranial magnetic stimulation (rTMS) is thought to partly exert its antidepressant action through the serotonergic system. Accelerated rTMS may have the potential to result in similar but faster onset of clinical improvement compared to the classical daily rTMS protocols, but given that delayed clinical responses have been reported, the neurobiological effects of accelerated paradigms remain to be elucidated including on this ...

The Impact of Accelerated HF-rTMS on Canine Brain Metabolism Vrije Universiteit Brussel

Kathelijne Peremans, Jan Courtyn, Kurt Audenaert, Yves D'Asseler, Eric Achten, Jimmy Saunders, Chris Baeken

Background: Repetitive transcranial magnetic stimulation (rTMS) has been proven to be a useful tool for the treatment of several severe neuropsychiatric disorders. Accelerated (a)rTMS protocols may have the potential to result in faster clinical improvements, but the effects of such accelerated paradigms on brain function remain to be elucidated.

Objectives: This sham-controlled arTMS study aimed to evaluate the immediate and delayed ...

The Impact of Accelerated HF-rTMS on the Subgenual Anterior Cingulate Cortex in Refractory Unipolar Major Depression Vrije Universiteit Brussel Universiteit Gent

Chris Baeken, Daniele Marinazzo, Hendrik Everaert, Guo-Rong Wu, Christian Van Hove, Kurt Audenaert, Ingeborg Goethals, Filip De Vos, Kathelijne Peremans, Rudi De Raedt, et al.

BACKGROUND: Although one of the most frequent diagnosed mental illnesses worldwide, it appears to be challenging to successfully treat major depressive disorder (MDD). Although the phenomenon of treatment-resistant depression (TRD) still remains unclear, the subgenual anterior cingulate cortex (sgACC) has been put forward as a possible neurobiological marker to evaluate clinical effects of a variety of antidepressant treatments, including ...

The impact of one session of HF-rTMS on salivary cortisol in healthy female subjects Universiteit Gent

Chris Baeken, Rudi De Raedt, Lemke Leyman, Johan Schiettecatte, Kris Poppe, Leon Kaufman, Margot Haes, Marie-Anne Vanderhasselt, Ellen Anckaert, Hugo D'Haenen, et al.
Previous studies in healthy volunteers reported a possible impact of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on stress hormones, like cortisol. In this sham-controlled, "single blind'', crossover study, we examined whether HF-rTMS had an effect on the hypothalamic-pituitary-adrenal (HPA) axis, by analysing salivary cortisol levels. Two studies were conducted. First, HF-rTMS on the left dorsolateral prefrontal cortex ...

No influence of one right-sided prefrontal HF-rTMS session on alcohol craving in recently detoxified alcohol-dependent patients: Results of a naturalistic study Vrije Universiteit Brussel

Sarah Herremans, Chris Baeken, Nathalie Vanderbruggen, M.a. Vanderhasselt, Dieter Zeeuws, Liesbeth Santermans, R. De Raedt
Background: Prior research in substance dependence has suggested potential anti-craving effects of repetitive transcranial magnetic stimulation (rTMS) when applied to the dorsolateral prefrontal cortex (DLPFC). However, no single sham-controlled session studies applied to the right DLPFC have been carried-out in recently detoxified alcohol-dependent patients. Furthermore, no studies examined the effect of a single HF-rTMS session on craving in ...

Right prefrontal HF-rTMS attenuates right amygdala processing of negatively valenced emotional stimuli in healthy females. Vrije Universiteit Brussel

Chris Baeken, Rudi De Raedt, Peter Van Schuerbeek, Marie-Anne Vanderhasselt, Johan De Mey, Axel Bossuyt, Robert Luypaert
Repetitive transcranial magnetic stimulation (rTMS) studies investigating brain imaging correlates of emotion modulation in healthy volunteers can improve our understanding of the 'affective' impact of this application. In this fMRI study, we focused on lateralized amygdala functioning when processing salient emotional visual stimuli after one high-frequency (HF)-rTMS session. In a 'uniform sample' of 20 right-handed, non-depressed, healthy ...

Intensive HF-rTMS treatment in refractory medication-resistant unipolar depressed patients. Vrije Universiteit Brussel

Chris Baeken, Marie-Anne Van Der Hasselt, Jonathan Remue, Sarah Herremans, Nathalie Vanderbruggen, Dieter Zeeuws, Liesbeth Santermans, Rudi De Raedt
BACKGROUND:

Major depression is a worldwide severe mental health problem. Unfortunately, not all depressed patients respond to pharmacotherapy or psychotherapy, even when adhering to treatment guidelines. Even though current guidelines do not in particular advocate repetitive Transcranial Magnetic Stimulation (rTMS) in refractory treatment resistant depression (TRD), using more intensive stimulation parameters might hold promise as a ...

HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression. Vrije Universiteit Brussel Universiteit Gent

Chris Baeken, Rudi De Raedt, Liesbeth Santermans, Dieter Zeeuws, Marie-Anne Vanderhasselt, M. Meers, Nathalie Vanderbruggen
Repetitive Transcranial Magnetic Stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising treatment strategy for depression. As one of the key features of melancholic depression is disturbances in psychomotor activity, we wanted to evaluate whether HF-rTMS treatment could influence psychomotor symptoms. Twenty antidepressant-free unipolar melancholic depressed patients, all at least stage III ...

Longer depressive episode duration negatively influences HF-rTMS treatment response Vrije Universiteit Brussel Universiteit Gent

Guo-Rong Wu, Chris Baeken

Repetitive transcranial magnetic stimulation (rTMS) is an evidence based neurostimulation modality used to treat patients with Major Depressive Disorder (MDD). In spite that the duration of current a depressive episode has been put forward as a negative predictor for clinical outcome, little is known about the underlying neurobiological mechanisms of this phenomenon. To address this important issue, in a sample of 43 melancholic stage III ...

Self-directedness: An indicator for clinical response to the HF-rTMS treatment in refractory melancholic depression Vrije Universiteit Brussel

Chris Baeken, Stefanie Desmyter, Romain Duprat, Rudi De Raedt, Dirk Van denabbeele, Hannelore Tandt, Gilbert M. D. Lemmens, Myriam Vervaet, Kees van Heeringen
Although well-defined predictors of response are still unclear, clinicians refer a variety of depressed patients for a repetitive Transcranial Magnetic Stimulation (rTMS) treatment. It has been suggested that personality features such as Harm Avoidance (HA) and self-directedness (SD) might provide some guidance for a classical antidepressant treatment outcome. However, to date no such research has been performed in rTMS treatment paradigms. In ...