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Are VIDAS® anti-HEV IgM and IgG assays fit for reliable diagnosis of hepatitis E virus infections? Comparison & case story telling Universiteit Gent Instituut voor Tropische Geneeskunde

Koen Vercauteren, Elizaveta Padalko
Objectives: Hepatitis E virus (HEV) genotype 3 is an emerging pathogen in developed countries. We evaluated the performance of two new serological assays for the detection of HEV, VIDAS (R) anti-HEV IgM and IgG. Methods: VIDAS (R) assays were performed on 77 clinical samples: 68 samples from patients suspected for HEV infection and 9 samples which previously tested positive for HEV IgM, IgG or HEV PCR. All samples were also tested using Wantai ...

Hepatitis E virus (HEV) open reading frame 2 antigen kinetics in human-liver chimeric mice and its impact on HEV diagnosis Universiteit Gent

Ibrahim Ibrahim Mahmoud Sayed, Lieven Verhoye, Claire Montpellier, Florence Abravanel, Jacques Izopet, Laurence Cocquerel, Philip Meuleman
Background. Hepatitis E virus infection (HEV) is an emerging problem in developed countries. Diagnosis of HEV infection is based on the detection of HEV-specific antibodies, viral RNA, and/or antigen (Ag). Humanized mice were previously reported as a model for the study of HEV infection, but published data were focused on the quantification of viral RNA. However, the kinetics of HEV Ag expression during infection remains poorly understood. ...

Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective Instituut voor Tropische Geneeskunde

Eline L M Op de Coul, Susan J M Hahné, J W M Yolanda van Weert, Petra J Oomen, Colette Smit, C P B Kitty van der Ploeg, Daan W Notermans, Kees Boer, Marianne A B van der Sande

BACKGROUND: A screening programme for pregnant women has been in place since the 1950s in the Netherlands. In 2004 universal HIV screening according to opting out was implemented. Here, we describe the evaluation of the effectiveness of antenatal screening in the Netherlands for 2006-2008 for HIV, hepatitis B virus (HBV) and syphilis in preventing mother-to-child transmission, by using various data sources.

METHODS: The results of ...

Prenatale screening op hiv, hepatitis B en syfilis in Nederland effectief Instituut voor Tropische Geneeskunde

Eline L M Op de Coul, J W M Yolanda van Weert, Petra J Oomen, Colette Smit, C P B Kitty van der Ploeg, Susan J M Hahné, Daan W Notermans, Marianne van der Sande
Abstract
Objective: Evaluation of the effectiveness of antenatal screening in the Netherlands for HIV, hepatitis B virus (HBV) and syphilis, in preventing mother-to-child transmission.

Design: Descriptive.

Methods: The results of antenatal screening in the period 2006-2008 were compared with data from pregnant women and newborns from other data sources.

Results: Each year, around 185,000 pregnant women were screened for ...

Wing morphometrics as a possible tool for the diagnosis of the Ceratitis fesciventris, C. anonae, C. rosa complex (Diptera, Tephritidae) Universiteit Antwerpen

Joannes Van Cann, Massimiliano Virgilio, Kurt Jordaens, Marc De Meyer
Previous attempts to resolve the Ceratitis FAR complex (C. fasciventris, C. anonae, C. rosa, Diptera, Tephritidae) showed contrasting results and revealed the occurrence of five microsatellite genotypic clusters (A, F1, F2, R1, R2). In this paper we explore the potential of wing morphometrics for the diagnosis of FAR morphospecies and genotypic clusters. We considered a set of 227 specimens previously morphologically identified and genotyped at ...

Biotin interferences Vrije Universiteit Brussel

Jean-Louis Bayart, Julien Favresse, Anke Stoefs, Mélanie Closset, Tatiana Roy, Catherine Fillée, Hector Rodriguez-Villalobos, Damien Gruson

BACKGROUND: Biotin has been reported to be a leading cause of interference on several immunoassay platforms using the streptavidin-biotin immobilization system. While biotin interferences have now been well characterized for several assays, only few data are available on their impact on serological markers of infectious viral diseases.

METHODS: Overall, 10 healthy volunteers (HVs) received a single 100 mg dose of biotin to evaluate ...

Diagnostic and prognostic scoring systems for autoimmune hepatitis: A review Vrije Universiteit Brussel Universiteit Gent

O. Ducazu, Helena Degroote, Ann Geerts, Anne Hoorens, Jacoba Schouten, Geen naam beschikbaar, Xavier Verhelst
Introduction: Auto-immune hepatitis (AIH) is a rare condition which primarily affects young women. Several diagnostic scoring systems exist based on clinical, biochemical, immunologic and histologic characteristics of AIH. Additionally, prognostic parameters can be identified. The purpose of this literature review is to compare the clinical value, strengths and limitations of these diagnostic and prognostic scoring systems. Methods: A literature ...

Strategies to manage hepatitis C virus (HCV) disease burden Universiteit Hasselt KU Leuven Universiteit Gent Universiteit Antwerpen

H. Wedemeyer, A. S. Duberg, M. Buti, W. M. Rosenberg, S. Frankova, G. Esmat, N. Ormeci, H. Van Vlierberghe, M. Gschwantler, U. Akarca, et al.
The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can ...