A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of regulatory T cells in cancer Universiteit Gent Vlaams Instituut voor Biotechnologie KU Leuven
A metabolic CRISPR-Cas9 screen reveals the important role of fucosylation in the suppressive function of Tregs. Measuring fucosylation in Tregs has the potential to aid in the discovery of relevant prognostic markers for cancer patients. Forkhead box P3 (Foxp3)-expressing regulatory T cells (Treg) are the guardians of controlled immune reactions and prevent the development of autoimmune diseases. However, in the tumor context, their increased ...