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Developmental pharmacokinetics and safety of ibuprofen and its enantiomers in the conventional pig as potential pediatric animal model Universiteit Gent
Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of the drug. Recently, the conventional growing piglet has been suggested as juvenile animal model. However, more studies with different classes of drugs are warranted to make a thorough evaluation ...
In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach Universiteit Gent
The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled. While the in vitro ontogeny of pig biotransformation enzymes is getting more attention in literature, the in vivo developmental changes have not yet been investigated. Therefore, the aim of the ...
Adsorption and photocatalytic removal of Ibuprofen by activated carbon impregnated with TiO2 by UV-Vis monitoring Universiteit Hasselt
The removal of Ibuprofen was investigated by activated carbon impregnated with TiO2. Emphasis was given on the effect of different parameters, such as composite type, initial Ibuprofen concentration (5 -25 mg/L), temperature (22-28 degrees C) and pH (acidic and alkaline solution). The experiment was carried out in a self-made tubular flow reactor, with one 15 W monochromatic UV lamp (254 nm). The composite AC90T10 gives the highest removal ...
Ibuprofen als alternatief voor antibiotica bij urineweginfecties? Universiteit Gent
Kan een behandeling met ibuprofen in plaats van met fosfomycine het aantal antibioticakuren verminderen zonder de duur van de symptomen te verlengen en zonder het risico op herval en ernstige complicaties te verhogen bij volwassen vrouwen met een ongecompliceerde urineweginfectie?Achtergrond: Gerandomiseerde gecontroleerde studies die antibiotica vergeleken met placebo voor de behandeling van ongecompliceerde cystitis bij vrouwen, toonden aan ...
Ion mobility spectrometry as a high-throughput technique for in vitro transdermal Franz diffusion cell experiments of ibuprofen Universiteit Gent
A Novel Malonamide Periodic Mesoporous Organosilica (PMO) for tuneable ibuprofen release Universiteit Gent
Expectant management or early ibuprofen for patent ductus arteriosus Universiteit Gent Vrije Universiteit Brussel Universiteit Antwerpen
BACKGROUND Cyclooxygenase inhibitors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs is uncertain. METHODS In this multicenter, noninferiority trial, we randomly assigned infants with echocardiographically confirmed PDA (diameter, >1.5 mm, with left-to-right shunting) who were extremely preterm (<28 weeks’ gestational age) to receive either expectant management or early ibuprofen treatment. ...
Ibuprofen does not Impair Skeletal Muscle Regeneration Upon Cardiotoxin-Induced Injury KU Leuven
Muscle regeneration is regulated through interaction between muscle and immune cells. Studies showed that treatment with supra-physiological doses of Non-Steroidal Anti-Inflammatory Drug (NSAID) abolished inflammatory signaling and impaired muscle recovery. The present study examines the effects of pharmacologically-relevant NSAID treatment on muscle regeneration. C57BL/6 mice were injected in the tibialis anterior (TA) with either PBS or ...
Using Physiologically Based Pharmacokinetic Modeling to Assess the Risks of Failing Bioequivalence Criteria: a Tale of Two Ibuprofen Products KU Leuven
The aims of the proposed study were to develop and verify a quantitative model-based framework to anticipate the in vivo bioequivalence of ibuprofen immediate release formulations. This stepwise approach integrated virtual bioequivalence trials to simulate the test to reference (T/R) ratio for positive (i.e., bioequivalent) and negative (i.e., non-bioequivalent) control formulations containing ibuprofen, approximated distribution of ...