Publicaties

The process of granuloma formation is complex, and due to species differences, the validity of animal studies is somewhat questioned. Moreover, the large number of animals needed to observe the different stages of development also raises ethical questions. Therefore, researchers have explored the use of human peripheral blood mononuclear cells (PBMCs), a heterogeneous population of immune cells, in an in vitro model. This review included in ...

The coconut palm (Cocos nucifera L.) is the second most important palm crop in the world and its production has an estimated yearly value of US $11.5 billion. Most coconut plantations are owned by smallholders. Currently, there are many old non-productive plantations in need of replanting. However, new quality palms are expensive and will not produce during several years. The price of the planting material is high due to its intensive production ...

As gardens get smaller, the demand for potted and compact cultivars of woody ornamentals increases. Therefore, the goal of this project is to develop protocols for alternative in vitro breeding methods to induce compactness within Elaeagnus, Escallonia, Osmanthus and Sarcococca.
A collection of species and cultivars has been compiled and contains 28 Elaeagnus, 25 Escallonia, 18 Osmanthus and 16 Sarcococca species. We will characterize our ...

Drug-induced intrahepatic cholestasis (DIC) is a main type of hepatic toxicity that is challenging to predict in early drug development stages. Preclinical animal studies often fail to detect DIC in humans. In vitro toxicogenomics assays using human liver cells have become a practical approach to predict human-relevant DIC. The present was set up to identify transcriptomic signatures of DIC by applying machine learning algorithms to the Open ...

The pervasiveness of oral bacterial infections in diabetic patients is a serious health concern that may produce severe complications. We investigated 26 Ayurvedic medicinal plants traditionally used for treatment of the oral bacterial infections with the aim to look for new promising drug leads that can be further employed for herbal formulation design. The plants were grouped into three categories based on traditional usage. All plant extracts ...

The expression of certain bacterial genes is regulated in a cell-density dependent way, a phenomenon called quorum sensing. Both Gram-negative and Gram-positive bacteria use this type of communication, though the signal molecules (auto-inducers) used by them differ between both groups: Gram-negative bacteria use predominantly N-acyl homoserine lacton (AHL) molecules (autoinducer-1, AI-1) while Gram-positive bacteria use mainly peptides ...

Fruits from the Citrus genus are broadly demanded for their flavor, nutri
tional value, and health benefits. Among the various biological activities of Citrus, antiallergic activity has been reported for some species, such as C. reticulata, C. medica, Citrus japonica, Citrus ×aurantifolia, and Citrus ×aurantium. These species have been shown to inhibit various allergic reactions, such as type I, II, and IV, in different pharmacological ...

Aim: Dens Invaginatus (DI) is a rare malformation of the teeth, showing a broad spectrum of morphologic variations. The aim of this study was to perform in vitro radiographic analyses of three extracted dens invaginatus (DI) teeth with complex root anatomy using plain radiographs, CBCT, MRI and micro CT techniques. Materials and methods Study Design: Three maxillary lateral incisors (A, 8 and C) from two patients were extracted due to poor ...