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Soil-transmitted helminthiasis: the relationship between prevalence and classes of intensity of infection Universiteit Gent

Antonio Montresor, Natacha à Porta, Marco Albonico, Albis Francesco Gabrielli, Dina Jankovic, Christopher Fitzpatrick, Jozef Vercruysse, Bruno Levecke
Background: Recently, WHO has developed a predictive model to evaluate the impact of preventive chemotherapy programs to control the morbidity of soil-transmitted helminths (STHs). To make predictions, this model needs baseline information about the proportion of infections classified as low, moderate and high intensity, for each of the three STH species. However, epidemiological data available are often limited to prevalence estimates. Methods: ...

Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations Universiteit Gent

Anna E. Savage, Carly R. Muletz-Wolz, Evan H. Campbell Grant, Robert C. Fleischer, Kevin Mulder
Infectious diseases are causing catastrophic losses to global biodiversity. Iridoviruses in the genus Ranavirus are among the leading causes of amphibian disease-related mortality. Polymorphisms in major histocompatibility complex (MHC) genes are significantly associated with variation in amphibian pathogen susceptibility. MHC genes encode two classes of polymorphic cell-surface molecules that can recognize and bind to diverse pathogen peptides. ...

Assessing Onchocerca volvulus intensity of infection and genetic diversity using mitochondrial genome sequencing of single microfilariae obtained before and after ivermectin treatment Universiteit Antwerpen

Shannon M. Hedtke, Young-Jun Choi, Anusha Kode, Gowtam C. Chalasani, Neha Sirwani, Stephen R. Jada, An Hotterbeekx, Michel Mandro, Joseph Nelson Siewe Fodjo, Glory Ngongeh Amambo, et al.
Onchocerciasis is a neglected tropical disease targeted for elimination using ivermectin mass administration. Ivermectin kills the microfilariae and temporarily arrests microfilariae production by the macrofilariae. We genotyped 436 microfilariae from 10 people each in Ituri, Democratic Republic of the Congo (DRC), and Maridi County, South Sudan, collected before and 4-5 months after ivermectin treatment. Population genetic analyses identified ...