Publicaties
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Identification of a nonlinear model for a glucoregulatory benchmark problem Vrije Universiteit Brussel
Recently, a novel identification method for a nonlinear dynamic model, called nonlinear Linear Fractional Representation (NL-LFR) model, has been developed. The model, composed of a static nonlinearity (SNL) surrounded by linear dynamics, can account for both nonlinear feed-forward and nonlinear feed-back effects. Using two classical frequency response measurements, the SNL is automatically recovered in a user-friendly and efficient ...
Divergent dynamics in systemic and tissue-specific metabolic and inflammatory responses during weight loss in subjects with obesity Universiteit Gent
Aim: Dysfunction of adipose and muscle tissue associates with obesity-related co-morbidities such as insulin resistance (IR) and inflammation. This study investigates changes in systemic and tissue-specific markers of IR and inflammation after gastric bypass surgery (GBS) in subjects with obesity. Methods: Prospective study, twenty subjects with obesity (50 +/- 10 years, 14 men). Prior to, and six months and one year after GBS, subcutaneous ...
The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial KU Leuven
OBJECTIVE: We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity. DESIGN: Multicentre randomised controlled trial. ...
Comparison of several data-driven non-linear system identification methods on a simplified glucoregulatory system example Vrije Universiteit Brussel
In this study, several advanced data-driven non-linear identification techniques are compared on a specific problem: a simplified glucoregulatory system modelling example. This problem represents a challenge in the development of an artificial pancreas for Type 1 diabetes mellitus treatment, since for this application good non-linear models are needed to design accurate closed-loop controllers to regulate the glucose level in the blood. ...