Publicaties

1 - 10 of 19 resultaten

Sorteren op
Zoek term:

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis Instituut voor Tropische Geneeskunde

Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M. Starks, Claudia Emerson, Debra Hanna, Peter S. Kim, Richard Liwski, Matteo Zignol, et al.

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.

Raw genotype-phenotype correlation data were extracted as part of a comprehensive systematic review to develop a standardised analytical approach for interpreting resistance associated mutations for rifampicin, isoniazid, ...

Factors associated with mortality in persons co-infected with tuberculosis and HIV in Suriname: a retrospective cohort study Universiteit Hasselt

Deborah STIJNBERG, Eric Commiesie, Diana Marin, Ward SCHROOTEN, Freddy Perez, Mauro Sanchez
Objective. To identify socio-demographic and clinical factors associated with mortality among persons with tuberculosis (TB) and TB/HIV co-infection in Suriname. Methods. This was a retrospective cohort study using data from the national TB and HIV databases for 2010 2015. The survival probability of TB and TB/HIV co-infected patients was analyzed using the Kaplan-Meier estimates and the log-rank test. A Cox proportional hazard model was ...

Evaluation of the intensified tuberculosis case finding guidelines for children living with HIV Universiteit Antwerpen

S. Sawry, H. Moultrie, Annelies Van Rie
SETTING: Out-patient paediatric human immunodeficiency virus (HIV) clinic in Soweto, South Africa. OBJECTIVE: To evaluate the yield of symptom screening for intensified tuberculosis (TB) case finding (ICF) and potential eligibility for isoniazid preventive therapy (IPT) in children living with HIV on antiretroviral treatment (ART). DESIGN: A cohort of 247 children (age 0-8 years) was systematically screened for TB symptoms during the first 2 ...

Stigma as a barrier to the use of occupational health units for tuberculosis services in South Africa Universiteit Antwerpen

Nina Sommerland, Edwin Wouters, Caroline Masquillier, M. Engelbrecht, G. Kigozi, K. Uebel, A. Janse van Rensburg, A. Rau
SETTING: Tuberculosis (TB) is the leading cause of death in South Africa, and health care workers (HCWs) are disproportionally affected. The resulting absenteeism strains the already overburdened health system. Although hospital occupational health care units (OHUs) are cost-effective and of crucial importance in tackling the TB epidemic, the fear of being stigmatised by other colleagues might lead HCWs to avoid using OHUs. OBJECTIVE : To ...

Cost-effectiveness of the Three I's for HIV/TB and ART to prevent TB among people living with HIV. KU Leuven

Somya Gupta
OBJECTIVE: To evaluate the cost-effectiveness of the Three I's for HIV/TB (human immunodeficiency virus/tuberculosis): antiretroviral therapy (ART), intensified TB case finding (ICF), isoniazid preventive treatment (IPT), and TB infection control (IC). METHODS: Using a 3-year decision-analytic model, we estimated the cost-effectiveness of a base scenario (55% ART coverage at CD4 count ⩿350 cells/mm(3)) and 19 strategies that included one or more ...

A home tracing program for contacts of people with tuberculosis or HIV and patients lost to care Universiteit Antwerpen

C. B. Deery, C. F. Hanrahan, K. Selibas, J. Bassett, I. Sanne, Annelies Van Rie
SETTING: Primary care clinic serving a high tuberculosis (TB) and human immunodeficiency virus (HIV) prevalence community in South Africa. OBJECTIVE: To evaluate a program combining TB and HIV contact investigation with tracing of individuals lost to TB or HIV care. DESIGN: Contacts were offered home-based HIV testing, TB symptom screening, sputum collection and referral for isoniazid preventive therapy (IPT). Effectiveness was assessed by the ...

Utilization of HIV and tuberculosis services by health care workers in Uganda: implications for occupational health policies and implementation Universiteit Antwerpen

Esther Buregyeya, Fred Nuwaha, Rhoda K. Wanyenze, Ellen M.H. Mitchell, Bart Criel, Suzanne Verver, Simon Kasasa, Robert Colebunders
Background: Access to HIV testing and subsequent care among health care workers (HCWs) form a critical component of TB infection control measures for HCWs. Challenges to and gaps in access to HIV services among HCWs may thus compromise TB infection control. This study assessed HCWs HIV and TB screening uptake and explored their preferences for provision of HIV and TB care. Methods: A cross-sectional mixed-methods study involving 499 HCWs and 8 ...

Incidence, risk factors and interventions addressing mortality associated with HIV and TB infections among children and adults in Kenya Instituut voor Tropische Geneeskunde

Dickens Otieno Onyango
Tuberculosis (TB) and infection with human immuno-deficiency virus (HIV) are leading infectious causes of morbidity particularly in sub-Saharan Africa, which is disproportionately affected by the two epidemics. Kenya is one of the 30 countries with the highest HIV and TB burden in the world. Kenya’s HIV prevalence was estimated to be 4,900 per 100,000 in 2019 while TB prevalence was 558 per 100,000 population in a 2016 survey. Estimates of ...

TB/HIV integration at primary care level Universiteit Antwerpen

L. Page-Shipp, Y. Voss De Lima, K. Clouse, J. de Vos, L. Evarts, J. Bassett, I. Sanne, Annelies Van Rie
Background. In 2004 the World Health Organization (WHO) released the Interim Policy on Collaborative TB/HIV activities. According to the policy, for people living with HIV (PLWH), activities include intensified case finding, isoniazid preventive therapy (IPT) and infection control. For TB patients, activities included HIV counselling and testing (HCT), prevention messages, and cotrimoxazole preventive therapy (CPT), care and support, and ...