Publicaties
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Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis Universiteit Gent
Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their specific structure, chromatographic analysis often requires special buffer systems or the use of trifluoroacetic acid, limiting mass spectrometry ...
Development of correct kinetic plot methods for SFC Universiteit Gent
Critical evaluation of various kinetic plot methods for SFC system performance prediction and comparison with HPLC Universiteit Gent
Application of the isopycnic kinetic plot method for elucidating the potential of sub-2 µm and core-shell particles in SFC Universiteit Gent
The kinetic plot method applied to gradient chromatography: theoretical framework and experimental validation Universiteit Gent
Application of the isopycnic kinetic plot method for elucidating the potential of sub-2 micron and core/shell particles in SFC Universiteit Gent
One of the many advantages that Supercritical fluid chromatography (SFC) is attributed with over high performance liquid chromatography (HPLC) is that it should be possible to use longer columns and/or columns packed with smaller particles at higher velocities. This is due to the higher diffusivity of analytes in supercritical fluids compared to liquids (higher optimum mobile phase velocity) and to the lower viscosity of the mobile phases in SFC ...
Investigation of the validity of the kinetic plot method to predict the performance of coupled column systems operated at very high pressures under different thermal conditions Universiteit Gent
The present study investigates how strong the kinetic plot method is influenced by the changes in plate height, retention factor and apparent column permeability that arise under conditions of very high pressure. More precisely, the study investigates how well a set of performance measurements conducted on a single short column can be used to predict the performance of a long sequence of coupled columns. This has been investigated for the two ...
Kinetic plot method as a tool to design coupled column systems producing 100,000 theoretical plates in the shortest possible time Universiteit Gent
The present paper reports on the possibility to use the kinetic plot method (KPM) to select and design the best possible system to achieve a given number (100,000) of theoretical plates for a pharmaceutical test mixture, using the information obtained from a series of single Column performance measurements of sub-2 mu m and supra-2 mu m porous shell particles conducted at three different temperatures and using mixtures of acetonitrile and 0.1% ...
Kinetic plot method as a tool to design coupled column systems producing 100 000 theoretical plates in the shortest possible time Vrije Universiteit Brussel
Kinetic plot method as a tool to design coupled column systems producing 100 000 theoretical plates in the shortest possible time