Publicaties
Pharmacology of novel drugs against visceral leishmaniasis and African trypanosomiasis Universiteit Antwerpen
Habitat productivity and pyrethroid susceptibility status of Aedes aegypti mosquitoes in Dar es Salaam, Tanzania Universiteit Antwerpen
RNA interference of Hsp70 in Artemia franciscana nauplii and its effect on morphology, growth, survival and immune response Universiteit Gent
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study KU Leuven Universiteit Gent Universiteit Antwerpen
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells KU Leuven
Pinpointing molecular mechanisms of long non-coding RNAs : at the crossroads of biochemistry and genetics Universiteit Gent
Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4 KU Leuven
JunB is a key regulator of multiple myeloma bone marrow angiogenesis Vrije Universiteit Brussel
Bone marrow (BM) angiogenesis significantly influences disease progression in multiple myeloma (MM) patients and correlates with adverse prognosis. The present study shows a statistically significant correlation of the AP-1 family member JunB with VEGF, VEGFB, and IGF1 expression levels in MM. In contrast to the angiogenic master regulator Hif-1α, JunB protein levels were independent of hypoxia. Results in tumor-cell models that allow the ...
Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells Vrije Universiteit Brussel
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of mechanisms which largely depend on the vesicle origin and recipient cell type. The aim of the present study was to identify the mechanisms involved in the uptake of BMSC-derived small EVs (sEVs) ...