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Gynaecomastie als presenterend symptoom bij een patiënt met longkanker KU Leuven
Gynaecomastia as presenting symptom in a patient with lung cancer The medical history of a 66-year-old male exsmoker diagnosed with non-small-cell lung cancer after developing painful unilateral gynaecomastia is presented. Large-cell lung carcinoma can be associated with marked elevations of serum hCG, causing gynaecomastia due to an imbalance between the stimulatory effect of estrogens and the inhibitory effect of androgens. In adult patients ...
Opsporen van risicopatiënten voor longkanker in de eerste lijn Universiteit Gent
Breathomics: niet-invasieve ademanalyse voor longkanker diagnose Universiteit Gent
Wordt er tegemoetgekomen aan de wensen van patiënten voor informatie en participatie in de medische besluitvorming? Een interviewstudie bij longkankerpatiënten. Vrije Universiteit Brussel
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Excellent response to MEK inhibition in an AGK-BRAF gene fusion driven carcinoma Universiteit Antwerpen
Background: Soft tissue myoepithelial carcinomas (STMC) are a rare, malignant subgroup of myoepithelial tumors that arise typically in glandular or ductal tissues, but also in the bone and soft and cutaneous tissues. Due to its rarity, there is no consensus regarding the treatment of STMC, including chemotherapy or other systemic agents for metastatic STMC. Case Report: A chemotherapy- and regorafenibrefractory STMC, harboring an AGK-BRAF ...
The well-being of physicians during the COVID-pandemic in a Belgian tertiary hospital Universiteit Antwerpen
Background: COVID-19 has become the largest medical challenge worldwide, affecting the physical and mental well-being of physicians. The aim of this study was to explore the well-being of physicians during the second wave of the COVID-19 outbreak in a Belgian tertiary hospital, with special attention to anaesthesiologists. They were confronted with overcrowded intensive care units, were mentally challenged during several months by an ...
Characterization of acquired nutlin-3 resistant non-small cell lung cancer cells Universiteit Antwerpen
Aim: The purpose of this manuscript is to study the potential characteristics of acquired nutlin-3 resistant non-small cell lung cancer cells (NSCLC). Nutlin-3 is an inhibitor of the murine-double minute 2 protein, the main negative regulator of wild type p53, of which several derivatives are currently in clinical development. Methods: A549 NSCLC cells were exposed to increasing concentrations of nutlin-3 for a period of 18 weeks. Monoclonal ...
Cancer-associated fibroblasts as a common orchestrator of therapy resistance in lung and pancreatic cancer Universiteit Antwerpen
Cancer arises from mutations accruing within cancer cells, but the tumor microenvironment (TME) is believed to be a major, often neglected, factor involved in therapy resistance and disease progression. Cancer-associated fibroblasts (CAFs) are prominent and key components of the TME in most types of solid tumors. Extensive research over the past decade revealed their ability to modulate cancer metastasis, angiogenesis, tumor mechanics, ...