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Transmission potential of paromomycin-resistant Leishmania infantum and Leishmania donovani Universiteit Antwerpen
Objectives Former studies demonstrated quick selection of paromomycin resistance for Leishmania infantum and Leishmania donovani accompanied by increased fitness. The present study aimed to interpret these findings in an epidemiological context by comparing infection of WT and experimentally derived paromomycin-resistant strains in the sand fly vector. Methods Depending on the Leishmania species, Lutzomyia longipalpis and Phlebotomus perniciosus ...
Expression of a rK39 homologue from an Iranian Leishmania infantum isolate in Leishmania tarentolae for serodiagnosis of visceral leishmaniasis Instituut voor Tropische Geneeskunde
Background: Kinesin-related gene diversity among strains and species of Leishmania may impact the sensitivity and specificity of serodiagnostic tests for visceral leishmaniasis (VL).
Methods: In this study, we report on the recombinant expression of this novel Iranian Leishmania infantum (MCAN14/47) homologue of rK39 (Li-rK39), in L. tarentolae. The diagnostic potential of the Li-rK39 antigen was evaluated in an ELISA, using ...
In vitro time-to-kill assay to assess the cidal activity dynamics of current reference drugs against Leishmania donovani and Leishmania infantum Universiteit Antwerpen
Objectives: Despite a continued search for novel antileishmanial drugs, treatment options remain restricted to a few standard drugs, e. g. antimonials, miltefosine, amphotericin B and paromomycin. Although these drugs have now been used for several decades, their mechanism of action still remains partly hypothetical and their dynamics of cidal action and time-to-kill are still poorly documented. Methods: An in vitro time-to-kill assay on ...
Application of PCR-RFLP for the exploration of the molecular diversity of Leishmania infantum in Algeria Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Application of molecular techniques in the study of natural infection of Leishmania infantum vectors and utility of sandfly blood meal digestion for epidemiological surveys of leishmaniasis Instituut voor Tropische Geneeskunde
Epidemiological studies on the distribution of leishmaniasis caused by Leishmania infantum Nicolle, 1908 (Kinetoplastida: Trypanosomatidae) have been based principally on serological surveys of the canine reservoir. This methodology is useful due to the facility of sampling, the rapidity in obtaining results, its consistency and because it allows the detection of heterogeneous foci of canine leishmaniasis (CanL) even in small areas. Other ...