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Toxicity report of a phase 1/2 dose-escalation study in patients with inoperable, locally advanced nonsmall cell lung cancer with helical tomotherapy and concurrent chemotherapy. Vrije Universiteit Brussel

S. Bral, Michael Duchateau, H. Versmessen, Douwe Erwin Verdries, Benedikt Engels, Mark De Ridder, Koen Tournel, Christine Collen, Hendrik Everaert, Denis Schallier, et al.
BACKGROUND: The objective of the current study was to evaluate the feasibility and toxicity of radiation dose escalation with concurrent chemotherapy using helical tomotherapy (HT) in patients with inoperable, locally advanced, stage III nonsmall cell lung cancer (LANSCLC) (grading determined according to the American Joint Committee on Cancer 6th edition grading system). METHODS: This phase 1/2 study was designed to determine the maximum ...

The Authors reply: Comment on: "Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy" by Burtin et al. Universiteit Hasselt

Chris BURTIN, Jacques Bezuidenhout, Karin J. C. Sanders, Anne-Marie C. Dingemans, Annemie M. W. J. Schols, Stephanie T. H. Peeters, Martijn A. SPRUIT, Dirk K. M. De Ruysscher
The Authors reply: Comment on: "Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy" by Burtin et al. We want to thank Dr Shafieesabet and Dr Doehner for the critical appraisal 1 of our findings. 2 The normative values for handgrip strength based on UK Biobank data include the 5th, 10th, and 25th percentile. While the authors propose the 5th percentile as cutoff to ...

Geriatric Assessment and Functional Decline in Older Patients with Lung Cancer Vrije Universiteit Brussel KU Leuven

Lore Decoster, C Kenis, Denis Schallier, J. Vansteenkiste, K Nackaerts, Leen Vanacker, N Vandewalle, J. Flamaing, J.p. Lobelle, K. Milisen, et al.

PURPOSE: Older patients with lung cancer are a heterogeneous population making treatment decisions complex. This study aims to evaluate the value of geriatric assessment (GA) as well as the evolution of functional status (FS) in older patients with lung cancer, and to identify predictors associated with functional decline and overall survival (OS).

METHODS: At baseline, GA was performed in patients ≥70 years with newly diagnosed lung ...

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy Vrije Universiteit Brussel

Charles A Kunos, Jeffrey M Fabien, John P Shanahan, Christine Collen, Thierry Gevaert, Kenneth Poels, Robbe Van den Begin, Benedikt Engels, Mark De Ridder

Physicians considering stereotactic ablative body radiation therapy (SBRT) for the treatment of extracranial cancer targets must be aware of the sizeable risks for normal tissue injury and the hazards of physical tumor miss. A first-of-its-kind SBRT platform achieves high-precision ablative radiation treatment through a combination of versatile real-time imaging solutions and sophisticated tumor tracking capabilities. It uses dual-diagnostic ...

Stereotactic body radiotherapy (SBRT) for the treatment of inoperable stage I non-small cell lung cancer patients Universiteit Antwerpen

L. Ceniceros, J. Aristu, E. Castanon, Christian Rolfo, J. Legaspi, A. Olarte, G. Valtuena, M. Moreno, I. Gil-Bazo
Lung cancer is the most frequent neoplasm in humans. Surgery is considered the best therapeutic approach for stage I non-small lung cell cancer (NSCLC). However, a remarkable amount of patients are considered as inoperable. Stereotactic body radiotherapy (SBRT) has risen as an option for those patients, rendering excellent results in quality of life and survival. We analyzed clinical studies published between 2002 and 2015 which included SBRT as ...

Contouring workload in adjuvant breast cancer radiotherapy Vrije Universiteit Brussel

V. A. Andrianarison, M. Laouiti, O. Fargier-Bochaton, G. Dipasquale, X. Wang, Ngoc Dung Nguyen, R. Miralbell, Vincent Vinh - Hung

Purpose: To measure the impact of contouring on worktime in the adjuvant radiation treatment of breast cancer, and to identify factors that might affect the measurements. Material and methods: The dates and times of contouring clinical target volumes and organs at risk were recorded by a senior and by two junior radiation oncologists. Outcome measurements were contour times and the time from start to approval. The factors evaluated were ...

Gating and tracking, 4D in thoracic tumours Vrije Universiteit Brussel

Dirk Verellen, Tom Depuydt, Thierry Gevaert, Nadine Linthout, Koen Tournel, Michael Duchateau, Truus Reynders, Guy Storme, Mark De Ridder
The limited ability to control for a tumour's location compromises the accuracy with which radiation can be delivered to tumour-bearing tissue. The resultant requirement for larger treatment volumes to accommodate target uncertainty restricts the radiation dose because more surrounding normal tissue is exposed. With image-guided radiation therapy (IGRT), these volumes can be optimized and tumouricidal doses may be delivered, achieving maximum ...

The METABANK score Vrije Universiteit Brussel

Robbe Van den Begin, Benedikt Engels, Christine Collen, Tessa de Vin, Arne Defauw, Emilie Dubaere, Kurt Barbé, Mark De Ridder

BACKGROUND AND PURPOSE: Stereotactic radiotherapy (SRT, SBRT) is widely used in oligometastatic cancer, but the heterogeneity of the population complicates estimation of the prognosis. We investigated the role of different clinical and inflammatory parameters.

MATERIALS AND METHODS: We included all patients treated with SRT for 1-5 oligometastases between 2003 and 2017 in our center. Patients were randomized between a model training ...

Small airways function in breast cancer patients before and after radiotherapy Vrije Universiteit Brussel

Sylvia Verbanck, Shane Wendy Hanon, Daniël Schuermans, Hilde Van Parijs, Vincent Vinh-Hung, Geertje Miedema, Dirk Verellen, Guy Storme, Marian Vanhoeij, Jan Lamote, et al.
Radiotherapy treatments for early stage breast cancer patients potentially affect the lung in its most distal air spaces, and previous studies have indicated consistently low baseline values for diffusing capacity in breast cancer patients. We aimed to quantitatively assess baseline small airway function and the acute effects of radiotherapy in breast cancer patients with no confounding effects from respiratory disease or considerable smoking ...

Intensity modulated radiotherapy induces pro-inflammatory and pro-survival responses in prostate cancer patients Instituut voor Tropische Geneeskunde Universiteit Gent

Houssein El-Saghire, Charlot Vandevoorde, Piet Ost, Pieter Monsieurs, Arlette Michaux, Gert De Meerleer, Sarah Baatout, Hubert Thierens

Intensity modulated radiotherapy (IMRT) is one of the modern conformal radiotherapies that is widely used within the context of cancer patient treatment. It uses multiple radiation beams targeted to the tumor, however, large volumes of the body receive low doses of irradiation. Using γ-H2AX and global genome expression analysis, we studied the biological responses induced by low doses of ionizing radiation in prostate cancer patients ...