Publicaties
Genetica van het chronischevermoeidheidssyndroom Universiteit Antwerpen
In dit artikel wordt een systematisch overzicht gegeven van wat reeds gekend is over de genetische basis van de neuro-endocriene ontregelingen in het chronischevermoeidheidssyndroom (CVS), meer specifiek in het cortisol en het monoaminesysteem. CVS kent een multifactoriële pathogenese. De meest gerepliceerde en consistente bevindingen wijzen op een ontregeling van het neurobiologisch stresssysteem. Daarnaast zijn er aanwijzingen dat de ...
Determination of the potential tumor-suppressive effects of Gsdme in a chemically induced and in a genetically modified intestinal cancer mouse model Universiteit Antwerpen Vrije Universiteit Brussel
Gasdermin E (GSDME), also known as deafness autosomal dominant 5 (DFNA5) and previously identified to be an inducer of regulated cell death, is frequently epigenetically inactivated in different cancer types, suggesting that GSDME is a tumor suppressor gene. In this study, we aimed to evaluate the tumor-suppressive effects of GSDME in two intestinal cancer mouse models. To mimic the silencing of GSDME by methylation as observed in human cancers, ...
Identification of genes contributing to human complex diseases and traits in the genetically isolated Saami and the general European population Universiteit Antwerpen
Laagmoleculaire Heparinen in de Pediatrie: een overzicht. Universiteit Gent
Genetically encoded biosensors based on innovative scaffolds KU Leuven
Genetically encoded biosensors are indispensable tools for visualizing the spatiotemporal dynamics of analytes or processes in living cells in vitro and in vivo. Their widespread adaptation has gone hand in hand with the development of sensors for new analytes or processes and improved functionality and robustness. In this review, we highlight some of the recent advances in genetically encoded biosensor development, with a special focus on novel ...
Optimizing the use of zebrafish feeding trials for the safety evaluation of genetically modified crops Universiteit Antwerpen Universiteit Gent
In Europe, the toxicological safety of genetically modified (GM) crops is routinely evaluated using rodent feeding trials, originally designed for testing oral toxicity of chemical compounds. We aimed to develop and optimize methods for advancing the use of zebrafish feeding trials for the safety evaluation of GM crops, using maize as a case study. In a first step, we evaluated the effect of different maize substitution levels. Our results ...
Physiologic functions of PP2A: Lessons from genetically modified mice KU Leuven
Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most cases, further bound to a regulatory B-type subunit. The B-type subunits determine function and regulation of PP2A trimers, but despite their importance in PP2A biology, their roles in controlling dephosphorylation of a given substrate in a given cell or tissue remain poorly defined, ...
Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution KU Leuven
Compartmentalized biochemical activities are essential to all cellular processes, but there is no generalizable method to visualize dynamic protein activities in living cells at a resolution commensurate with cellular compartmentalization. Here, we introduce a new class of fluorescent biosensors that detect biochemical activities in living cells at a resolution up to threefold better than the diffraction limit. These 'FLINC' biosensors use ...