Novel genetic tools to study the molecular basis of drug resistance in Trypanosoma congolense Instituut voor Tropische Geneeskunde
Trypanosoma congolense is the main parasite causing Animal African Trypanosomiasis (AAT) with dev-astating consequences to livestock health and economics in sub-Saharan Africa. Isometamidium Chlo-ride (ISM) is one of the principle drugs used against the disease. While resistance to ISM has become problematic, its mechanisms are yet to be discovered. Transporter proteins are of utmost interest in drug development as they allow the drug to enter ...