Publicaties
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Seeing God’s glory : Van Eyck's optical lore in the sixteenth century Universiteit Gent
This essay discusses the devotional efficacy of the Ghent Altarpiece’s sophisticated naturalistic style and its problematic reception in the sixteenth century. Drawing on recent scientific insights uncovered during the current restoration campaign of the famous polyptych, we concur with the conclusions of other scholars that Eyckian naturalism is grounded in profound knowledge of the late-medieval science of optics. Simultaneously, we argue that ...
Pan-cancer analysis of whole genomes Universiteit Antwerpen Universiteit Gent Vrije Universiteit Brussel
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas ...
Software for the frontiers of quantum chemistry: An overview of developments in the Q-Chem 5 package KU Leuven
This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange-correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with ...
Reducing the environmental impact of surgery on a global scale : systematic review and co-prioritization with healthcare workers in 132 countries Universiteit Gent Vrije Universiteit Brussel
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist ...
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset Universiteit Antwerpen
Background: There is increasing evidence that Parkinson's disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain is already destroyed, so that the lack of early biomarkers for the disease represents a major challenge for developing timely treatment interventions. Here, we use a transgenic ...
In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study KU Leuven Universiteit Antwerpen Vrije Universiteit Brussel
AIMS: Previous research suggests that patients undergoing upper gastrointestinal surgery are at high risk of poor postoperative outcomes. The aim of our study was to describe patient outcomes after elective upper gastrointestinal surgery at a global level. METHODS: Prospective analysis of data collected during an international seven-day cohort study of 474 hospitals in 27 countries. Patients undergoing elective upper gastrointestinal surgery ...
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery KU Leuven Universiteit Antwerpen Vrije Universiteit Brussel
BACKGROUND: The incidence and impact of postoperative complications are poorly described. Failure-to-rescue, the rate of death following complications, is an important quality measure for perioperative care but has not been investigated across multiple health care systems. METHODS: We analysed data collected during the International Surgical Outcomes Study, an international 7-day cohort study of adults undergoing elective inpatient surgery. ...
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries Vrije Universiteit Brussel KU Leuven
Background
As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care.
Methods
We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death ...
As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care.
Methods
We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death ...