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Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing-remitting Multiple Sclerosis (ASIIMS) trial Universiteit Hasselt Universiteit Antwerpen Vrije Universiteit Brussel

Richard E. Gonsette, Christian Sindic, Marie B. D'hooghe, Peter-Paul De Deyn, Rob MEDAER, Alex Michotte, Pierrette Seeldrayers, Daniel Guillaume
Anti-inflammatory drugs are effective on relapses, but neuroprotective agents to prevent disability are still unavailable. Uric acid has neuroprotective effects in experimental models including encephalomyelitis and appears to be involved in multiple sclerosis. Oral administration of inosine, a precursor of uric acid, increases serum uric acid levels and is well tolerated. Our objective was to test the possibility that a combination therapy ...

From "Wheelchair Circuit" to "Wheelchair Assessment Instrument for People With Multiple Sclerosis": Reliability and Validity Analysis of a Test to Assess Driving Skills in Manual Wheelchair Users With Multiple Sclerosis KU Leuven

Monia Vereecken
OBJECTIVES: To assess the reliability and validity of the Wheelchair Assessment Instrument for people with Multiple Sclerosis (WAIMS), a test to measure driving skills in manual wheelchair users with multiple sclerosis (MS). DESIGN: Three test trials per subject were conducted by 2 raters to examine reliability (inter- and intrarater) and validity (concurrent and construct). SETTING: A national multiple sclerosis rehabilitation center. ...

The Multiple Sclerosis Data Alliance Catalogue; Enabling Web-Based Discovery of Metadata from Real-World Multiple Sclerosis Data Sources Universiteit Hasselt KU Leuven

Lotte GEYS, Tina PARCIAK, Ashkan PIRMANI, Robert McBurney, Hollie Schmidt, Tanja Malbaša, Tjalf Ziemssen, Arnfin Bergmann, Juan I. Rojas, Edgardo Cristiano, et al.
Background: One of the major objectives of the Multiple Sclerosis Data Alliance (MSDA) is to enable better discovery of multiple sclerosis (MS) real-world data (RWD). Methods: We implemented the MSDA Catalogue, which is available worldwide. The current version of the MSDA Catalogue collects descriptive information on governance, purpose, inclusion criteria, procedures for data quality control, and how and which data are collected, including the ...

‘‘How to conquer a mountain with multiple sclerosis’’. How a climbing expedition to Machu Picchu affects the way people with multiple sclerosis experience their body and identity: a phenomenological analysis Universiteit Hasselt Vrije Universiteit Brussel

Joeri CALSIUS, Imke COURTOIS, Peter FEYS, Paul VAN ASCH, Jozef De Bie, Marie D'Hooghe
BACKGROUND: People with multiple sclerosis (MS) frequently complain of chronic or fluctuating fatigue, sometimes accompanied by pain. From a phenomenological point of view, both fatigue and pain are seen as aspects of suffering which adversely affect the physical, psychological, social and even existential dimensions of the individual life. OBJECTIVE: The present study discusses changes in identity and body awareness in people with MS who ...

Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the "power training in older multiple sclerosis patients (PoTOMS) randomized control trial Universiteit Hasselt

Tobias Gaemelke, Christoffer Laustsen, Peter FEYS, Lars Folkestad, Marianne Skovsager Andersen, Niklas Rye Jorgensen, Marie-Louise Jorgensen, Sune Norhoj Jespersen, Steffen Ringgaard, Simon F. Eskildsen, et al.
Introduction: Approximately one-third of all persons with multiple sclerosis (pwMS) are older, i.e., having an age >= 60 years. Whilst ageing and MS separately elicit deteriorating effects on brain morphology, neuromuscular function, and physical function, the combination of ageing and MS may pose a particular challenge. To counteract such detrimental changes, power training (i.e., a type of resistance exercise focusing on moderate-to-high ...

Assessing the effect of an evidence-based patient online educational tool for people with multiple sclerosis called UMIMS-understanding magnetic resonance imaging in multiple sclerosis Vrije Universiteit Brussel

Insa Schiffmann, Magalie Freund, Eik Vettorazzi, Jan-Patrick Stellmann, Susanne Heyer-Borchelt, Marie-Beatrice, Vivien Häußler, Anne Christin Rahn, Christoph Heesen

BACKGROUND: While magnetic resonance imaging (MRI) plays a major role in the lives of people with multiple sclerosis (pwMS), studies have shown that MRI-specific knowledge in pwMS is limited. Moreover, poor knowledge was associated with negative feelings towards MRI (e.g. anxiety concerning MRI scan). Because information sources about MRI in MS for pwMS are not available, we designed and evaluated an evidence-based online educational platform ...

The Role of Cerebral Hypoperfusion in Multiple Sclerosis (ROCHIMS) Trial in Multiple Sclerosis Vrije Universiteit Brussel

Stéphanie Hostenbach, Hubert Raeymaekers, Peter Van Schuerbeek, Anne-Marie Van Binst, Wilfried Cools, Jacques De Keyser, Miguel D'Haeseleer

Background: Accumulating evidence indicates that mitochondrial energy failure is involved in the progressive axonal degeneration in multiple sclerosis (MS). In patients with MS, it has been shown that both levels of N-acetylaspartate (NAA), which is a marker of axonal mitochondrial energy, and cerebral blood flow (CBF) are reduced in cerebral normal appearing white matter (NAWM). The latter is likely due to the vasoconstrictive action of ...

Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers Universiteit Hasselt

Mina Mohammadinasr, Soheila Montazersaheb, Ommoleila Molavi, Houman KAHROBA, Mahnaz Talebi, Hormoz Ayromlou, Mohammad Saeid Hejazi
Exosomal microRNAs (miRNAs) are emerging diagnostic biomarkers for neurodegenerative diseases. In this study, we aimed to detect relapsing-remitting multiple sclerosis (RRMS)-specific miRNAs in cerebrospinal fluid (CSF) and serum exosomes with diagnostic potential. One ml of CSF and serum sample were collected from each of the 30 untreated RRMS patients and healthy controls (HCs). A panel of 18 miRNAs affecting inflammatory responses was ...

"How to conquer a mountain with multiple sclerosis''. How a climbing expedition to Machu Picchu affects the way people with multiple sclerosis experience their body and identity: a phenomenological analysis KU Leuven

Imke Courtois
BACKGROUND: People with multiple sclerosis (MS) frequently complain of chronic or fluctuating fatigue, sometimes accompanied by pain. From a phenomenological point of view, both fatigue and pain are seen as aspects of suffering which adversely affect the physical, psychological, social and even existential dimensions of the individual life. OBJECTIVE: The present study discusses changes in identity and body awareness in people with MS who ...

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis KU Leuven

An Goris, Philip Van Damme, Wim Robberecht, Bénédicte Dubois
Genome-wide association studies (GWAS) have been successful in identifying common variants that influence the susceptibility to complex diseases. From these studies it has emerged that there is substantial overlap in susceptibility loci between diseases. In line with those findings, we hypothesized that shared genetic pathways may exist between multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). While both diseases may have ...