C-(4-[F-18]fluorophenyl)-N-phenyl nitrone: A novel F-18-labeled building block for metal free [3+2]cycloaddition KU Leuven
Synthesis and evaluation of F-18-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease KU Leuven
Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages Vrije Universiteit Brussel
PURPOSE: Macrophage mannose receptor (MMR, CD206) expressing tumor-associated macrophages (TAM) are protumorigenic and was reported to negatively impact therapy responsiveness and is associated with higher chances of tumor relapse following multiple treatment regimens in preclinical tumor models. Since the distribution of immune cells within the tumor is often heterogeneous, sampling "errors" using tissue biopsies will occur. In order to ...
Increased 18F-FDG Uptake in the Obturator Muscles Due to Denervation-Driven Atrophy Vrije Universiteit Brussel
Evaluation of [ 99mTc]Radiolabeled Macrophage Mannose Receptor-Specific Nanobodies for Targeting of Atherosclerotic Lesions in Mice Vrije Universiteit Brussel
Purpose: Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaque hemorrhage and neovascularization. It has been proposed as target to identify vulnerable plaques. Therefore, we aimed to ...
Unilaterally Decreased Striatal Dopamine Transporter Caused by Venous Anomaly Vrije Universiteit Brussel
We describe a finding of unilaterally decreased binding of 123I-ioflupane in the basal ganglia in a 78-year-old woman that could be attributed to an underlying developmental venous anomaly.
PSMA Uptake in Mediastinal Sarcoidosis Vrije Universiteit Brussel
Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein which is frequently overexpressed on prostate cancer cells. Ga-PSMA PET/CT plays an increasing role in prostate cancer management. However, growing evidence suggests increased PSMA uptake in a variety of other malignant tumor entities and in some benign lesions. This report describes PSMA uptake in numerous thoracic lymph nodes in a patient with known mediastinal ...