Optimal Experimental Design for Efficient Optical Manipulation of Magnetic Beads Seeded in a Microwell Array KU Leuven Universiteit Antwerpen
Problem: In the field of genomics, proteomics and disease diagnostics, it is of great interest to capture individual targets (e.g., cells, bacteria, exosomes) on magnetic beads and to seed them in a microwell array. Optical manipulation of the magnetic beads in the array then allows selecting the targets of interest and moving them to another location for post analysis. However, this technology is hampered by the low fraction of beads that show ...