Publicaties
The Value of 18F-FDG PET/CT in Predicting the Response to PD-1 Blocking Immunotherapy in Advanced NSCLC Patients with High-Level PD-L1 Expression Vrije Universiteit Brussel
BACKGROUND: The objective of this study was to evaluate if 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)-derived parameters are useful in predicting response and survival after programmed cell death protein 1 (PD-1) blocking immunotherapy in patients with advanced NSCLC characterized by a high programmed death-ligand 1 (PD-L1) expression (≥50%) on immunohistochemistry.
PATIENTS AND METHODS: ...
CD70 and PD-L1 in anaplastic thyroid cancer : promising targets for immunotherapy Universiteit Gent Universiteit Antwerpen KU Leuven
Challenging PD-L1 expressing cytotoxic T cells as a predictor for response to immunotherapy in melanoma Universiteit Gent
The Controversial Role of PD-1 and Its Ligands in Gynecological Malignancies Vrije Universiteit Brussel KU Leuven
The programmed death-1 (PD-1, CD279) receptor with its ligands, programmed death ligand 1 (PD-L1, CD274, B7-H1), and programmed death ligand 2 (PD-L2, CD273, B7-DC), are the key players of one of the immune checkpoint pathways inhibiting T-cell activation. PD-L1 and PD-L2 are expressed in different cancer cells and their microenvironment, including infiltrating immune cells. However, their prognostic value is still debated and their role in ...