Publicaties

BACKGROUND: This study characterizes the second hit spectrum in BRCA1 and BRCA2-associated breast and ovarian cancers at both gene loci to investigate if second hit mechanisms are mutually exclusive or able to coincide within the same tumor. METHODS: Loss of heterozygosity, somatic point mutations and copy number alterations along with promoter methylation were studied in 56 breast and 15 ovarian cancers from BRCA1 and BRCA2 germline mutation ...

Small, bowl-shaped pits characterized by a lower fill rich in charred organic material are among the most frequent features found on Mesolithic sites in the sand belt of NW Europe, in particular in the Netherlands and Belgium. Traditionally they are interpreted as U+201Cpit hearthsU+201D used for food processing and/or tar production. However, in 2015 the present authors suggested an alternative explanation according to which these features ...

A hybrid deterministic-probabilistic framework is presented that combines in-situ measurements and numerical analysis to predict the characteristic size of corrosion pits over extended periods of exposure to seawater. A probabilistic model, informed by corrosion current density and temperature data, applies a sampling method to a range of overpotential values to reflect the surface deterioration in terms of pitting. The model is calibrated and ...

Histamine receptors (HRs) are G-protein-coupled receptors involved in diverse responses triggered by histamine release during inflammation or by encounters with venomous creatures. Four histamine receptors (H1R-H4R) have been cloned and extensively characterized. These receptors are distributed throughout the body and their activation is associated with clinical manifestations such as urticaria (H1R), gastric acid stimulation (H2R), regulation ...