Publicaties

Deep proton writing ( DPW) is a fabrication technology developed for the rapid prototyping of polymer microstructures. We use polymethylmethacrylate (PMMA) substrates, which act as a positive resist, for irradiation with a collimated 12-MeV energy proton beam. Using 12 MeV enables the irradiation of increasingly thick PMMA substrates with less conicity of the sidewalls compared to the lower energies used in previous work. A microhole of 47.7 mu ...

Ever since the discovery of X-rays in 1895 by William Röntgen, radiotherapy has been a cornerstone in the cancer treatment. Nowadays, up to 50% of cancer patients are treated with radiotherapy during their course of illness. Despite many technical improvements in radiotherapy planning and delivery, X-ray or photon radiotherapy (XRT) is still associated with toxicity to normal tissue surrounding the tumor. Proton radiotherapy (PRT) is emerging as ...

Purpose: To provide a comparison between radiotherapy with photons, protons and carbon-ions in the treatment of Non-Small-Cell Lung Cancer (NSCLC), performing a meta-analysis of observational studies. Methods: Eligible studies on conventional radiotherapy (CRT), stereotactic radiotherapy (SBRT), concurrent chemoradiation (CCR), proton therapy and carbon-ion therapy were searched through a systematic review. To obtain pooled estimates of 2- and ...

PURPOSE: To compare dose to organs at risk (OARs) and dose-escalation possibility for 24 stage I non-small cell lung cancer (NSCLC) patients in a ROCOCO (Radiation Oncology Collaborative Comparison) trial. METHODS: For each patient, 3 photon plans [Intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and CyberKnife], a double scattered proton (DSP) and an intensity-modulated carbon-ion (IMIT) therapy plan were ...

Purpose: Particle therapy has potentially a better therapeutic ratio than photon therapy. However, investment costs are much higher. This study provides an estimation and comparison of the costs of these therapies.

Experimental cross section data for the production of 7Be by 9Be(d,x) 7Be reactions are presented for the first time at deuteron energies up to 50 MeV. For the 9Be(p,x) 7Be reaction values up to 65 MeV are presented and compared to literature values. The cross sections were measured using an activation method in stacked foil irradiations followed by gamma-ray spectroscopy. Thick target yields were calculated and discussed in comparison with ...

Combined measurements of the production and decay rates of the Higgs boson, as well as its couplings to vector bosons and fermions, are presented. The analysis uses the LHC proton-proton collision data set recorded with the CMS detector in 2016 at fb-1. The combination is based on analyses targeting the five main Higgs boson production mechanisms (gluon fusion, vector boson fusion, and associated production with a W or Z boson, or a top ...