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Effectiveness and safety of a time to isolation strategy of cryoballoon ablation of atrial fibrillation: A systematic review and meta-analysis Vrije Universiteit Brussel

Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A Gatzoulis, Gian Battista Chierchia, Carlo de Asmundis
Aim: We conducted a systematic review and meta-analysis of randomized and observational studies with a control group to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation (AF). Methods: Three electronic databases (MEDLINE, Cochrane Central Register of Controlled Trials, and Embase) without language restrictions were searched. The intervention ...

Effectiveness and safety of a time to isolation strategy of cryoballoon ablation of atrial fibrillation: A systematic review and meta-analysis Vrije Universiteit Brussel

Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A Gatzoulis, Gian Battista Chierchia, Carlo de Asmundis

Aim: We conducted a systematic review and meta-analysis of randomized and observational studies with a control group to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation (AF). Methods: Three electronic databases (MEDLINE, Cochrane Central Register of Controlled Trials, and Embase) without language restrictions were searched. The intervention ...

International severe asthma registry (ISAR) : protocol for a global registry Universiteit Gent

J. Mark FitzGerald, Trung N. Tran, Marianna Alacqua, Alan Altraja, Vibeke Backer, Leif Bjermer, Unnur Bjornsdottir, Arnaud Bourdin, Guy Brusselle, Lakmini Bulathsinhala, et al.
Background Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. Methods ISAR is a ...

The effect of exposure to long working hours on ischaemic heart disease : a systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury Universiteit Gent KU Leuven

Jian Li, Frank Pega, Yuka Ujita, Chantal Brisson, Els Clays, Alexis Descatha, Marco M. Ferrario, Lode Godderis, Sergio Iavicoli, Paul A. Landsbergis, et al.
Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are de- veloping Joint Estimates of the work -related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of experts. Evidence from mechanistic data suggests that exposure to long working hours may cause ischaemic heart disease (IHD). In this paper, we present a systematic review and meta - analysis of ...

Detectability vs. time and costs in pooled DNA extraction of cutaneous swabs : a study on the amphibian chytrid fungi Universiteit Gent

Joana Sabino-Pinto, E. Tobias Krause, Molly C. Bletz, An Martel, Frank Pasmans, Sebastian Steinfartz, Miguel Vences
Epidemiology relies on understanding the distribution of pathogens which often can be detected through DNA-based techniques, such as quantitative Polymerase Chain Reaction (qPCR). Typically, the DNA of each individual sample is separately extracted and undergoes qPCR analysis. However, when performing field surveys and long-term monitoring, a large fraction of the samples is generally expected to be negative, especially in geographical areas ...

Improving the diagnosis of peripheral arterial disease in below-the-knee arteries by adding time-resolved CT scan series to conventional run-off CT angiography. First experience with a 256-slice CT scanner Vrije Universiteit Brussel

Nico Buls, Yannick De Brucker, Dimitri Aerden, Hannes Devos, Gert Van Gompel, Pieter Boonen, Koenraad Nieboer, Tim Leiner, Johan De Mey

Purpose: Run-off Computed Tomography Angiography (run-off CTA) of the lower extremities has become the method of choice for the diagnostic imaging of patients suffering from peripheral arterial disease (PAD). However, it remains a challenging radiological examination with a considerable risk of non-diagnostic image quality for the assessment of below-the-knee arteries. In this study, we investigate the diagnostic benefit of adding ...

Azithromycin in labor lowers clinical infections in mothers and newborns: a double-blind trial Instituut voor Tropische Geneeskunde

Claire Oluwalana, Bully Camara, Christian Bottomley, Sean Goodier, Abdoulie Bojang, Beate Kampmann, Samba Ceesay, D'Alessandro, Anna Roca

BACKGROUND AND OBJECTIVES: We have recently completed a proof-of-concept trial showing that bacterial colonization decreased in women and newborns after the administration of azithromycin during labor. Here, we aim to assess the effect of the intervention on maternal and neonatal clinical infections.

METHODS: This was a double-blind, placebo-controlled randomized trial. Gambian women in labor were given either an oral dose of ...

Detection of Batrachochytrium dendrobatidis in Mexican bolitoglossine salamanders using an optimal sampling protocol Universiteit Gent

Pascale Van Rooij, An Martel, Joachim Nerz, Sebastian Voitel, Filip Van Immerseel, Freddy Haesebrouck, Frank Pasmans
The role of the chytrid fungus Batrachochytrium dendrobatidis (Bd), which is the causal agent of chytridiomycosis, in the declines of Central American bolitoglossine salamanders is unknown. Here we establish a swabbing protocol to maximize the detection probability of Bd in salamanders. We then used this protocol to examine captive and wild Mexican bolitoglossine salamanders of 14 different species for the presence of Bd. Of the seven body parts ...

Ethics of modifying the mitochondrial genome Universiteit Gent

A L Bredenoord, W Dondorp, Guido Pennings, G de Wert
Recent preclinical studies have shown the feasibility of specific variants of nuclear transfer to prevent mitochondrial DNA disorders. Nuclear transfer could be a valuable reproductive option for carriers of mitochondrial mutations. A clinical application of nuclear transfer, however, would entail germ-line modification, more specifically a germ-line modification of the mitochondrial genome. One of the most prominent objections against germ-line ...