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The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections Universiteit Gent

T Tängdén, V Ramos Martín, TW Felton, EI Nielsen, S Marchand, RJ Brüggemann, JB Bulitta, M Bassetti, U Theuretzbacher, BT Tsuji, et al.
Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing. The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients differ significantly from the patient groups from whose data the conventional dosing regimens were developed. Use of such regimens often results in inadequate antimicrobial concentrations at the site of infection and is associated with poor patient outcomes. In ...

Erratum to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC‑GLOSSARI): a multicenter, multinational, 14-day inception cohort study (Intensive Care Medicine, (2016), 42, 5, (953), 10.1007/s00134-016-4317-4) KU Leuven

Y Sakr, R Ferrer, K Reinhart, R Beale, A Rhodes, R Moreno, JF Timsit, L Brochard, BT Thompson, E Rezende, et al.
© 2017, Springer-Verlag GmbH Germany and ESICM. In both the original publication (DOI 10.1007/s00134-015-4206-2) and the first erratum (DOI 10.1007/s00134-016-4317-4), the members of the IC-GLOSSARI Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for these errors and is pleased to list the members of the groups here: (Table presented.).

Respiratory management in severe acute respiratory syndrome coronavirus 2 infection Universiteit Hasselt

Susanna Price, Suveer Singh, Stephane Ledot, Paolo Bianchi, Matthew Hind, Guido Tavazzi, Pascal VRANCKX
The severe acute respiratory syndrome coronavirus 2 pandemic is to date affecting more than a million of patients and is challenging healthcare professionals around the world. Coronavirus disease 2019 may present with a wide range of clinical spectrum and severity, including severe interstitial pneumonia with high prevalence of hypoxic respiratory failure requiring intensive care admission. There has been increasing sharing experience regarding ...

Incidence of influenza-like illness and severe acute respiratory infection during three influenza seasons in Bangladesh, 2008-2010 Instituut voor Tropische Geneeskunde

Eduardo Azziz-Baumgartner, A S M Alamgir, Mustafizur Rahman, Nusrat Homaira, Badrul Munir Sohel, M A Yushuf Sharker, Rashid Uz Zaman, Jacob Dee, Emily S Gurley, Abdullah A Mamun, et al.

OBJECTIVE: To determine how much influenza contributes to severe acute respiratory illness (SARI), a leading cause of death in children, among people of all ages in Bangladesh.

METHODS: Physicians obtained nasal and throat swabs to test for influenza virus from patients who were hospitalized within 7 days of the onset of severe acute respiratory infection (SARI) or who consulted as outpatients for influenza-like illness (ILI). A ...

Mortality, severe acute respiratory infection, and influenza-like illness associated with influenza A(H1N1)pdm09 in Argentina, 2009 Instituut voor Tropische Geneeskunde

Eduardo Azziz-Baumgartner, Ana María Cabrera, Loretta Chang, Rogelio Calli, Gabriela Kusznierz, Clarisa Baez, Pablo Yedlin, Ana María Zamora, Romina Cuezzo, Elena Beatriz Sarrouf, et al.

INTRODUCTION: While there is much information about the burden of influenza A(H1N1)pdm09 in North America, little data exist on its burden in South America.

METHODS: During April to December 2009, we actively searched for persons with severe acute respiratory infection and influenza-like illness (ILI) in three sentinel cities. A proportion of case-patients provided swabs for influenza testing. We estimated the number of case-patients ...

Predictors of severe H1N1 infection in children presenting within Pediatric Emergency Research Networks (PERN): retrospective case-control study Universiteit Gent

Stuart R Dalziel, John MD Thompson, Charles G Macias, Ricardo M Fernandes, David W Johnson, Yehezkel Waisman, Nicholas Cheng, Jason Acworth, James M Chamberlain, Martin H Osmond, et al.
Objective: To identify historical and clinical findings at emergency department presentation associated with severe H1N1 outcome in children presenting with influenza-like illness. Design: Multicentre retrospective case-control study. Setting: 79 emergency departments of hospitals associated with the Pediatric Emergency Research Networks in 12 countries. Participants: 265 children (<16 years), presenting between 16 April and 31 December 2009, ...

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells Universiteit Gent

Joline Ingels, Saskia De Smet, Kelly Heyns, Nele Lootens, Jonas Segaert, Tom Taghon, Karim Vermaelen, Evelyne Willems, Etienne Baudoux, Tessa Kerre, et al.
Objectives: Cytomegalovirus (CMV) infection is one of the most common complications in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. The classic antiviral treatments have shown clinical efficacy but are often associated with drug resistance. Reconstitution of CMV-specific cellular immunity is essential in controlling CMV infection; therefore, adoptive transfer of CMV-specific T cells is a promising treatment option. We ...

Risk factors associated with severe RSV infection in infants : what is the role of viral co-infections? Universiteit Gent Universiteit Antwerpen

Kim Stobbelaar, Thomas C. Mangodt, Winke Van der Gucht, Lise Delhaise, Jasmine Andries, Valerie Gille, Cyril Barbezange, Annemieke Smet, Benedicte Y. De Winter, Jozef J. De Dooy, et al.
The respiratory syncytial virus (RSV) represents the leading cause of viral lower respiratory tract infections (LRTI) in children worldwide and is associated with significant morbidity and mortality rates. The clinical picture of an RSV infection differs substantially between patients, and the role of viral co-infections is poorly investigated. During two consecutive winter seasons from October 2018 until February 2020, we prospectively included ...

Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection Vrije Universiteit Brussel

Jelle Smet, Dimitri Stylemans, Shane Wendy Hanon, Sylvia Verbanck, Eef Vanderhelst, Bart Ilsen

INTRODUCTION: Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study with assessment of residual symptoms, lung function and chest CT.

MATERIALS AND METHODS: During an outpatient follow-up visit, chest CT, pulmonary function and COVID-19 related symptoms were assessed approximately 10 weeks after diagnosis. Demographics, baseline (time of diagnosis) CT score and blood results were collected ...

Epidemiology of severe acute respiratory illness and risk factors for influenza infection and clinical severity among adults in Malawi, 2011-2013 Instituut voor Tropische Geneeskunde

Antonia Ho, Jane Mallewa, Ingrid Peterson, Miguel SanJoaquin, Shikha Garg, Naor Bar-Zeev, Mavis Menyere, Maaike Alaerts, Gugulethu Mapurisa, Moses Chilombe, et al.

Data on the epidemiology of severe acute respiratory illness (SARI) in adults from low-income, high human immunodeficiency virus (HIV) prevalence African settings are scarce. We conducted adult SARI surveillance in Blantyre, Malawi. From January 2011 to December 2013, individuals aged ≥ 15 years with SARI (both inpatients and outpatients) were enrolled at a large teaching hospital in Blantyre, Malawi. Nasopharyngeal aspirates were tested for ...