Publicaties
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A cell-based **in vitro** alternative to identify skin sensitizers by gene expression Universiteit Antwerpen
The ethical and economic burden associated with animal testing for assessment of skin sensitization has triggered intensive research effort towards development and validation of alternative methods. In addition, new legislation on the registration and use of cosmetics and chemicals promote the use of suitable alternatives for hazard assessment. Our previous studies demonstrated that human CD34+ progenitor-derived dendritic cells from cord blood ...
towards a mechanism-based **in vitro** screening assay for chemical-induced skin sensitization Universiteit Antwerpen
TLR1, TLR2, and TLR6 Gene Polymorphisms Are Associated With Increased Susceptibility to Complicated Skin and Skin Structure Infections Universiteit Hasselt
Background. Complicated skin and skin structure infections (cSSSIs) are characterized by infections with gram-positive or gram-negative aerobic or anaerobic bacteria, as well as by a polymicrobial etiology. These invading microorganisms are recognized by pattern-recognition receptors (PRRs) of the innate immune system. This study assessed whether genetic variation in genes encoding PRRs influences the susceptibility to cSSSIs. Methods. A total ...
The impact of skin care products on skin chemistry and microbiome dynamics Universiteit Gent
Background: Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9weeks. Results: Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal ...
Genetic Variation in TLR10, an Inhibitory Toll-Like Receptor, Influences Susceptibility to Complicated Skin and Skin Structure Infections Universiteit Hasselt
Background. Toll-like receptors (TLRs) play a central role in the innate immune response to complicated skin and skin structure infections (cSSSIs), with TLR10 being the first family member known to have an inhibitory function. This study assessed the role of TLR10 in recognition of cSSSI-related pathogens and whether genetic variation in TLR10 influences susceptibility to cSSSIs. Methods. Human peripheral blood mononuclear cells (PBMCs) ...
The role of community pharmacists in primary and secondary prevention of skin cancer : an evaluation of a Flemish skin cancer prevention campaign Universiteit Gent
BackgroundSkin cancer is a leading form of cancer in Belgium. Prevention of skin cancer by community pharmacists can play a role in increasing awareness and promoting sun protection. However, which persons could be reached by community pharmacists for skin cancer awareness in Belgium and whether this increased awareness is associated with increased sun protection and early detection remains unclear.MethodsDemographics of approached persons in ...
Using an Elastomeric Skin Protectant to Manage Donor Site Wounds of Split-thickness Skin Grafts Vrije Universiteit Brussel
Split-thickness skin grafting (STSG) is a common surgical procedure to manage acute and chronic wounds. A plethora of dressings exists to treat STSG donor site wounds (DSWs). Recently, a new elastomeric skin protectant was adopted (Cavilon Advanced Skin Protectant; 3M) in the treatment of incontinence-associated dermatitis. In this report, the authors assess the effects of this elastomeric skin protectant as an alternative wound dressing for ...
T-cell subsets in the skin and their role in inflammatory skin disorders Vrije Universiteit Brussel
T lymphocytes (T cells) are major players of the adaptive immune response. Naive T cells are primed in the presence of cytokines, leading to polarization into distinct T-cell subsets with specific functions. These subsets are classified based on their T-cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and their cytokine production, which together determine their specific function. This review ...
Evaluation of skin prick location on the forearm using a novel skin prick automated test device Universiteit Gent KU Leuven
BackgroundThe skin prick test (SPT) is the gold standard for identifying allergic sensitization in individuals suspected of having an inhalant allergy. Recently, it was demonstrated that SPT using a novel skin prick automated test (SPAT) device showed increased reproducibility and tolerability compared to the conventional SPT, among other benefits.ObjectiveThis study aimed to evaluate prick location bias using the novel SPAT device.MethodsA ...