Publicaties
Gekozen filters:
Gekozen filters:
Quality changes of pasteurised mango juice during storage. Part I: Selecting shelf-life markers by integration of a targeted and untargeted multivariate approach KU Leuven
For the first time, a multivariate approach combining targeted and untargeted data was used to obtain insight into quality changes in pasteurised mango juice (cv. ‘Totapuri’) as a function of storage (42 °C for 8 weeks). Mango juice samples were formulated with addition of different potential precursors for different quality-related chemical reactions: ascorbic acid, citric acid and sugars. Control (diluted mango puree with water), ascorbic ...
The Dynamics of Nucleotide Variants in the Progression from Low–Intermediate Myeloma Precursor Conditions to Multiple Myeloma: Studying Serial Samples with a Targeted Sequencing Approach Universiteit Hasselt KU Leuven
Simple Summary Multiple myeloma (MM), characterized by the expansion of plasma cells in the bone marrow, is the second most common hematological malignancy. This incurable cancer is consistently preceded by non-malignant asymptomatic precursor conditions known as monoclonal gammopathy of undetermined significance (MGUS) and/or smoldering multiple myeloma (SMM). These pre-stages are relatively frequent, but only a select percentage of them will ...
DNA diagnostics of hereditary hearing loss : a targeted resequencing approach combined with a mutation classification system Universiteit Gent Universiteit Antwerpen
The molecular signature of cross-modal brain plasticity in the mouse: development and application of a targeted plasma membrane proteomics approach KU Leuven
When a sensory system fails, the deprived cortical neurons can be recruited by the remaining senses and in parallel, sensory processing in the spared modalities will be refined to facilitate compensation for the sensory loss. Recently, our research group successfully introduced monocular enucleation (ME) as a model to investigate these so-called ‘cross-modal plasticity mechanisms’ in mouse visual system. After all, the contralateral visual ...
Hyperthermia in combination with emerging targeted and immunotherapies as a new approach in cancer treatment Universiteit Antwerpen
Simple Summary This manuscript discusses the ongoing challenge of cancer as a leading global cause of death despite advancements in therapies. It highlights the role of hyperthermia (HT) as a modality in cancer treatment, particularly its effectiveness as a sensitizer and its impact on cancer-immunity processes and oncogenic pathways. The article notes the recent focus on immunotherapy (IT) and targeted therapy (TT) in cancer research, both in ...
Biological and Clinical Implications of Gene-Expression Profiling in Diffuse Large B-Cell Lymphoma: A Proposal for a Targeted BLYM-777 Consortium Panel as Part of a Multilayered Analytical Approach KU Leuven
Gene-expression profiling (GEP) is used to study the molecular biology of lymphomas. Here, advancing insights from GEP studies in diffuse large B-cell lymphoma (DLBCL) lymphomagenesis are discussed. GEP studies elucidated subtypes based on cell-of-origin principles and profoundly changed the biological understanding of DLBCL with clinical relevance. Studies integrating GEP and next-generation DNA sequencing defined different molecular subtypes ...
Cognitive Functional Therapy: An Integrated Behavioral Approach for the Targeted Management of Disabling Low Back Pain KU Leuven
Biomedical approaches for diagnosing and managing disabling low back pain (LBP) have failed to arrest the exponential increase in health care costs, with a concurrent increase in disability and chronicity. Health messages regarding the vulnerability of the spine and a failure to target the interplay among multiple factors that contribute to pain and disability may partly explain this situation. Although many approaches and subgrouping systems ...
Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach KU Leuven
From a set of 292 Euphorbiaceae extracts, the use of a molecular networking (MN)-based prioritization approach highlighted three clusters (MN1-3) depicting ions from the bark extract of Codiaeum peltatum. Based on their putative antiviral potential and structural novelty, the MS-guided purification of compounds present in MN1 and MN2 afforded two new daphnane-type diterpenoid orthoesters (DDO), codiapeltines A (1) and B (2), the new actephilols ...
Study of the cell cycle interactome of Arabidopsis thaliana through a targeted proteomics approach Universiteit Gent
Defining protein complexes is critical to virtually all aspects of cell biology, because many cellular processes are regulated by stable protein complexes and their identification often provides insights into their function. In the introduction of the thesis, an overview is given on proteomic approaches with an emphasis towards study of protein-protein interactions and towards plant proteomic sudies. Next, we describe the development and ...