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Acute schistosomiasis in travelers: outcomes of a short-course therapy Instituut voor Tropische Geneeskunde

Jan CLERINX, Ula Maniewski-Kelner, Steven Van Den Broucke, Patrick Soentjens, Liselotte Cnops, Marjan Van Esbroeck, Emmanuel Bottieau

BACKGROUND: 

Therapy of acute schistosomiasis in travellers currently relies on poorly consistent combinations of corticosteroids and praziquantel. In a cluster of travellers recently infected with Schistosoma mattheei × Schistosoma haematobium hybrids during a trip to South Africa in 2017, we evaluated the safety and efficacy of short methylprednisolone cycles to suppress early symptoms and of a single-day ...

Behavioral intention to use parcel lockers in the last mile and underlying linkages with travel modal choice Vrije Universiteit Brussel

Eshwar Dayal, Lisa Khuntia, Lakshay Lakshay, Heleen Buldeo Rai, Agnivesh Pani
As e-commerce expands globally, using parcel lockers is becoming more and more common. Ultimately, our study contributes to a better understanding of last-mile delivery intents by providing insightful information to legislators and courier businesses seeking to encourage locker usage. After an online survey was completed in Mumbai, India, a Latent class cluster analysis and structural equation modeling were used to examine the variables ...

Trial characteristics, geographic distribution, and selected methodological issues of 1425 infertility trials published from 2012 to 2023: a systematic review KU Leuven

Thomas D'Hooghe
STUDY QUESTION: What are the trial characteristics, geographic distribution, and selected methodological issues of randomized controlled trials (RCTs) in infertility published from 2012 to 2023? SUMMARY ANSWER: Of the 1425 infertility RCTs, over two-thirds focused on IVF, nearly two-fifths did not use pregnancy or live birth as the primary outcome, a third lacked a primary outcome, a half were unregistered, and just over half were conducted in ...

Identification of a circulating carbohydrate antigen as a highly specific and sensitive target for schistosomiasis serology Instituut voor Tropische Geneeskunde

Anna O. Kildemoes, Tom Veldhuizen, ST Hilt, L. van Lieshout, T Supali, Maria Yazdanbakhsh, Daniel Camprubí-Ferrer, Jose Muñoz, J Clerinx, M Harvey, et al.
The World Health Organization (WHO) 2030 roadmap for schistosomiasis calls for development of highly sensitive and specific diagnostic tools to continue and sustain progress towards elimination. Serological assays are excellent for sensitive detection of primary schistosome infections and for schistosomiasis surveillance in near- and post-elimination settings. To develop accurate assay formats, it is necessary to identify defined antibody ...

Effect of studying abroad on catch-up vaccination in young adults: a study using the Japan Pretravel Consultation Registry Universiteit Antwerpen

Nobumasa Okumura, Kei Yamamoto, Noriko Iwamoto, Shinya Tsuzuki, Kenichi Hayashi, Koh Shinohara, Issaku Nakatani, Hidenori Nakagawa, Natsuko Imakita, Takashi Matono, et al.
Purpose: To investigate the effect of studying abroad on catch-up vaccination coverage for measles, rubella, mumps, varicella, and tetanus during the pretravel consultation among young adult travelers. Methods: This retrospective cohort study analyzed data from the Japan Pretravel Consultation Registry (J-PRECOR) on individuals aged 18-21 years with childhood vaccination records. Propensity score weighting was used to estimate the average ...

Congenital tuberculosis in a preterm neonate linked to female genital tuberculosis in a migrant mother: a case report Universiteit Antwerpen

Ludo Mahieu, Veerle Matheeussen
Highlights • Female genital tuberculosis increases infertility, prematurity, and perinatal tuberculosis risk in migrant mothers from high-incidence areas. • Visiting friends and relatives increases tuberculosis risk in migrants from high-endemic countries. • Diagnosis of congenital tuberculosis in newborns may be delayed due to co-infections and/or prematurity complications. • Surveillance gaps highlight need for extrapulmonary tuberculosis ...

Prevalence, clinical management, and outcomes of adults hospitalised with endemic arbovirus illness in southeast Europe (MERMAIDS-ARBO): a prospective observational study Universiteit Antwerpen

Katherine Loens, Herman Goossens, Margareta Ieven
Background Arboviruses have expanded into new regions in Europe, yet data indicate gaps in disease notifications and a risk of further spread. We aimed to report on prevalence, clinical management, and outcomes of endemic arbovirus infections in southeast Europe. Methods In this prospective observational study (MERMAIDS-ARBO), we enrolled adults (age >= 18 years) hospitalised with an arbovirus-compatible disease syndrome within 21 days of ...

Design and Implementation of a Proof-of-Concept Robotic-Microfluidic Interface to Bridge Spatial Comprehensive Three-Dimensional Liquid Chromatography with Mass Spectrometry Vrije Universiteit Brussel Vlaams Instituut voor Biotechnologie

Ali Amini, Thomas Themelis, Steven Janvier, Jan Steyaert, Jelle De Vos, Sebastiaan Eeltink

A proof-of-concept system is presented for the hyphenation of spatial comprehensive three-dimensional liquid chromatography (3D-LC) to mass spectrometry (MS) detection via a robotic-microfluidic interface. A three-dimensional fractal microflow distributor, incorporating 16 parallel RP monolithic capillary columns arranged in a 4 × 4 configuration, was connected to an X-Y-Z robotic system. This setup facilitated the deposition of successive ...

Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis KU Leuven

Laura Seldeslachts, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz Sharpe, Lander De Herdt, Simon Feys, Lieve Naesens, Patrick Matthys, Katrien Lagrou, Joost Wauters, et al.
BACKGROUND: Influenza-associated pulmonary aspergillosis (IAPA) is a severe fungal superinfection in critically ill influenza patients that is of incompletely understood pathogenesis. Despite the use of contemporary therapies with antifungal and antivirals, mortality rates remain unacceptably high. We aimed to unravel the IAPA immunopathogenesis as a means to develop adjunctive immunomodulatory therapies. METHODS: We used a murine model of IAPA ...

The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus KU Leuven

Bram Vrancken, Philippe Lemey
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. ...