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Chikungunya infection in returned travellers: results from the geosentinel network, 2005-2020 Instituut voor Tropische Geneeskunde

R Bierbrier, Emilie Javelle, FF Norman, Lin H. Chen, Emmanuel Bottieau, Eli Schwartz, Karin Leder, Kristina M Angelo, Rhett J. Stoney, Michael Libman, et al.
Background
Chikungunya is an important travel-related disease because of its rapid geographical expansion and potential for prolonged morbidity. Improved understanding of the epidemiology of travel-related chikungunya infections may influence prevention strategies including education and vaccination.

Methods
We analysed data from travellers with confirmed or probable chikungunya reported to GeoSentinel sites from 2005 to ...

Impact of HIV-1 infection on the humoral immune response to yellow fever vaccination: contribution to the development of a yellow fever vaccination schedule for patients living with HIV Instituut voor Tropische Geneeskunde

Charlotte Martin
Since the advent of modern and universal ART in our countries, PLWH have a life expectancy and lifestyle comparable to the general population. Many of them are travelling, either for tourism or to visit friends and relatives (VFR), including to yellow fever (YF) endemic destinations. They are therefore likely to be vaccinated against yellow fever. Since 2016, WHO guarantees administrative validity for life after YF vaccination, except for PLWH ...

Microscopic detection of intestinal Sarcocystis infection diagnosed in international travelers at the Institute of Tropical Medicine, Antwerp, Belgium, from 2001 to 2020 Instituut voor Tropische Geneeskunde

Steven Van Den Broucke, Pierre Dorny, Marjan Van Esbroeck, Emmanuel Bottieau

Although a stay in tropical regions is considered a risk factor for acquiring Sarcocystis infection, to date intestinal sarcocystosis has never been described in returning travelers. We did a retrospective cross-sectional study, retrieving all Sarcocystis spp. microscopy-positive stool results of individuals who attended the travel clinic of the Institute of Tropical Medicine, Antwerp in the period from 2001 to 2020. We reviewed the medical ...

Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis Instituut voor Tropische Geneeskunde

Gert Van der Auwera, Leigh Davidsson, Pierre Buffet, Marie-Thérèse Ruf, Marina Gramiccia, Stefania Varani, Carmen Chicharro, Aldert Bart, Gundel Harms, Peter L Chiodini, et al.

BackgroundSurveillance of human leishmaniasis in Europe is mostly limited to country-specific information from autochthonous infections in the southern part. As at the end of 2021, no integrated analysis has been performed for cases seen across centres in different European countries.AimTo provide a broad perspective on autochthonous and imported leishmaniasis cases in endemic and non-endemic countries in Europe.MethodsWe retrospectively ...

Analyses of clinical and biological data for French and Belgian immunocompetent patients infected with hepatitis E virus genotypes 4 and 3 Universiteit Antwerpen

Florence Micas, Vanessa Suin, Jean-Marie Péron, Caroline Scholtes, Edouard Tuaillon, Thomas Vanwolleghem, Laurence Bocket, Sébastien Lhomme, Chloé Dimeglio, Jecques Izopet, et al.
Hepatitis E virus (HEV) genotypes 3 and 4 are the major causes of acute hepatitis in industrialized countries. Genotype 3 is mainly found in Europe and America, while genotype 4 is predominant in Asia. Several Japanese studies have suggested that genotype 4 is more virulent than genotype 3. We investigated this aspect by analyzing the clinical and biological data for 27 French and Belgian immunocompetent patients infected with HEV genotype 4. ...

nosoi: A stochastic agent-based transmission chain simulation framework in r KU Leuven

Simon Dellicour, Philippe Lemey, Guy Baele
Abstract The transmission process of an infectious agent creates a connected chain of hosts linked by transmission events, known as a transmission chain. Reconstructing transmission chains remains a challenging endeavour, except in rare cases characterized by intense surveillance and epidemiological inquiry. Inference frameworks attempt to estimate or approximate these transmission chains but the accuracy and validity of such methods generally ...

Zika among international travelers presenting to GeoSentinel sites, 2012-2019: implications for clinical practice Instituut voor Tropische Geneeskunde

Kristina M Angelo, Rhett J. Stoney, Gaelle Brun-Cottan, Karin Leder, Martin P. Grobusch, Natasha Hochberg, Susan Kuhn, Emmanuel Bottieau, Patricia Schlagenhauf, Lin H. Chen, et al.

INTRODUCTION: International travellers contribute to the rapid spread of Zika virus (ZIKV) and its sentinel identification globally. We describe ZIKV infections among international travellers seen at GeoSentinel sites with a focus on ZIKV acquired in the Americas and the Caribbean, describe countries of exposure and traveller characteristics, and assess ZIKV diagnostic testing by site.

METHODS: Records with an international ...

Epidemiological and clinical characteristics of international travelers with enteric fever and antibiotic resistance profiles of their isolates: a GeoSentinel analysis Instituut voor Tropische Geneeskunde

Stefan H F Hagmann, Kristina M Angelo, Ralph Huits, Katherine Plewes, Gilles Eperon, Martin P. Grobusch, Anne E. McCarthy, Michael Libman, Eric Caumes, Daniel T. Leung, et al.

Enteric fever, caused by Salmonella enterica serovar Typhi ( S Typhi) and S. enterica serovar Paratyphi ( S Paratyphi), is a common travel-related illness. Limited data are available on the antimicrobial resistance (AMR) patterns of these serovars among travelers. Records of travelers with a culture-confirmed diagnosis seen during or after travel from January 2007 to December 2018 were obtained from GeoSentinel. Traveler demographics and ...

Case Report: Trypanosoma brucei Gambiense Human African Trypanosomiasis as the Cause of Fever in an Inpatient with Multiple Myeloma and HIV-1 Coinfection Instituut voor Tropische Geneeskunde

Carl Gregory Boodman, Michael Libman, Momar Ndao, Cedric Yansouni

We report the case of a 64-year-old woman found to have urban-acquired Trypanosoma brucei (T.b.) gambiense human African trypanosomiasis (HAT) as the cause of sustained fever starting 9 months after returning to Canada from Democratic Republic of the Congo, in the context of concomitant multiple myeloma and HIV-1 coinfection. Approaches for the management of both clinical stages of T.b. gambiense HAT are well defined for endemic settings ...