Publicaties

1 - 5 of 5 resultaten

Sorteren op
Zoek term:

Clinical evaluation of BioFire® multiplex-PCR panel for acute undifferentiated febrile illnesses in travellers: a prospective multicenter study Instituut voor Tropische Geneeskunde

Daniel Camprubí-Ferrer, Ludovico Cobuccio, Steven Van Den Broucke, Leire Balerdi-Sarasola, Blaise Genton, Emmanuel Bottieau, Jessica Navero-Castillejos, Miguel J. Martinez, Corinne Jay, Anne Grange, et al.

BACKGROUND: Identifying the causes of Acute Undifferentiated Febrile Illness (AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests (NAAT) targeting different relevant pathogens in travellers returning with fever.

METHODS: Prospective, multicentre study to evaluate a prototype panel in whole blood samples of adult ...

National and sub-national variation in patterns of febrile case management in sub-Saharan Africa Instituut voor Tropische Geneeskunde

Victor A Alegana, Joseph K Maina, Paul O Ouma, Peter Macharia, Jim Wright, Peter M Atkinson, Emelda A Okiro, Robert W Snow, Andrew J Tatem

Given national healthcare coverage gaps, understanding treatment-seeking behaviour for fever is crucial for the management of childhood illness and to reduce deaths. Here, we conduct a modelling study triangulating household survey data for fever in children under the age of five years with georeferenced public health facility databases (n = 86,442 facilities) in 29 countries across sub-Saharan Africa, to estimate the probability of seeking ...

Assessing viral metagenomics for the diagnosis of acute undifferentiated fever in returned travellers: a multicenter cohort study Instituut voor Tropische Geneeskunde

Daniel Camprubí-Ferrer, A Tomazatos, Leire Balerdi-Sarasola, LG Cobuccio, Steven Van Den Broucke, B Horváth, Marjan Van Esbroeck, Miguel J. Martinez, J Gandasegui, Carme Subirà, et al.
Background
Up to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centres. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, evidence of its usefulness in imported fever is very limited.

Methods
Travellers returning with fever were prospectively recruited in three referral clinics from November 2017 to November 2019. Unbiased ...

Epidemiology of travel-associated dengue from 2007 to 2022: A GeoSentinel analysis Instituut voor Tropische Geneeskunde

Alexandre Duvignaud, Rhett J. Stoney, Kristina M Angelo, Lin H. Chen, P Cattaneo, L Motta, Federico Giovanni Gobbi, Emmanuel Bottieau, Daniel L. Bourque, Corneliu Petru Popescu, et al.
Background
Dengue is a leading cause of febrile illness among international travellers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travellers evaluated at GeoSentinel sites from 2007 to 2022.

Methods
We retrieved GeoSentinel records of dengue among travellers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive dengue virus ...

Emerging souvenirs-clinical presentation of the returning traveller with imported arbovirus infections in Europe Universiteit Antwerpen

I. Eckerle, V. T. Briciu, O. Ergonul, M. Lupse, A. Papa, A. Radulescu, S. Tsiodras, C. Tsitou, C. Drosten, V. R. Nussenblatt, et al.
Background: Arboviruses are an emerging group of viruses that are causing increasing health concerns globally, including in Europe. Clinical presentation usually consists of a nonspecific febrile illness that may be accompanied by rash, arthralgia and arthritis, with or without neurological or haemorrhagic syndromes. The range of differential diagnoses of other infectious and noninfectious aetiologies is broad, presenting a challenge for ...